Amphiregulin

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Amphiregulin
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AREG ; AR; CRDGF; SDGF
External IDs OMIM104640 MGI88068 HomoloGene1252 ChEMBL: 3731 GeneCards: AREG Gene
Orthologs
Species Human Mouse
Entrez 374 11839
Ensembl ENSG00000109321 ENSMUSG00000029378
UniProt P15514 P31955
RefSeq (mRNA) NM_001657 NM_009704
RefSeq (protein) NP_001648 NP_033834
Location (UCSC) Chr 4:
75.31 – 75.32 Mb
Chr 5:
91.14 – 91.15 Mb
PubMed search [1] [2]

Amphiregulin, also known as AREG, is a protein that in humans is encoded by the AREG gene.[1][2][3]

Function[edit]

The protein encoded by this gene is a member of the epidermal growth factor family.[1]

It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the Epidermal growth factor receptor to promote the growth of normal epithelial cells.

Clinical signficance[edit]

Mutations in this encoded protein are associated with a psoriasis-like skin phenotype.[1]

References[edit]

  1. ^ a b c "Entrez Gene: AREG amphiregulin (schwannoma-derived growth factor)". 
  2. ^ Shoyab M, Plowman GD, McDonald VL, Bradley JG, Todaro GJ (February 1989). "Structure and function of human amphiregulin: a member of the epidermal growth factor family". Science 243 (4894 Pt 1): 1074–6. doi:10.1126/science.2466334. PMID 2466334. 
  3. ^ Plowman GD, Green JM, McDonald VL, Neubauer MG, Disteche CM, Todaro GJ, Shoyab M (May 1990). "The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity". Mol. Cell. Biol. 10 (5): 1969–81. PMC 360543. PMID 2325643. 

Further reading[edit]