Amprolium

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Amprolium
Amprolium.svg
Identifiers
CAS number 137-88-2 N
PubChem 2178
ChemSpider 66070 YesY
EC number 204-458-4
MeSH Amprolium
ChEMBL CHEMBL97350 YesY
ATCvet code QP51AX09
Jmol-3D images Image 1
Properties
Molecular formula C14H19N4+ · Cl
Molar mass 278.780 g·mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Amprolium (INN, trade names Amprovine, Amprolium, Amprol, Anticoccid) is a coccidiostat used in poultry.

Synthesis[edit]

Amprolium synth.png

The drug is a thiamine analogue and blocks the thiamine transporter of Eimeria species. By blocking thiamine uptake it prevents carbohydrate synthesis.

Despite only moderate efficacy it is well favoured due to few resistance issues and is commonly used in conjunction with sulfonamides prophylactically in chickens and cattle as a coccidiostat.

References[edit]

Sarett, Lewis H. (1960). "The hormones". Journal of Chemical Education 37 (4): 184. doi:10.1021/ed037p184.