Her professional experience ranges from dancer and backup singer for different Latin artists to acting in various movies. She has worked with artists.Her acting repertoire includes having the lead role in five episodes of Decisiones Puerto Rico and minor roles in the movies Yellow, El Cantante, and Talento de Barrio. She also has participated in musicals such as Fame, A Chorus Line and in High School Musical[vague]. In December 2007 she released her very first album called "Por El Amor" along with three singles, "Cuando No Estas", the second hit single in Puerto Rico "Quien Dijo Amigos", and "Dime". In 2009, she released a deluxe version of the album, along with a new single "Se Acabo" featuring Juan Velez, that was another radio hit in Puerto Rico. In November/2009 she won 1st place in Viva el Sueño, a TV reality show in univision. After this, she released her second album in Puerto Rico, but first internationally, "Mi Sueño". The album of covers is a collection of the many hits she sang on the show, Viva El Sueño. The first single released is "Por Amarte Así", featuring Cristian Castro, the original artist of the song.
On July 4, 2011; Ana Isabelle released her new single "La Vida Es Bella" ft. Chino y Nacho with her family. Then on August 12, 2011 she released the music video which contained some of her family in the last clip.