- This article is about structural analog representations. For other uses, see Analog (disambiguation).
Structural analogs (structural analogue or simply analog) are models or representations that keep each other certain "structural similarity". It is used in engineering, chemistry, mathematics and other fields.
In chemistry, a structural analog, (structural analogue), also known as chemical analog or simply analog, is a compound having a structure similar to that of another one, but differing from it in respect of a certain component.
It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound.
In drug discovery either a large series of structural analogs of an initial lead compound are created and tested as part of a structure-activity relationship study or a database is screened for structural analogs of a lead compound.
Chemical analogues of illegal drugs are developed and sold in order to circumvent laws. Such substances are often called designer drugs. Because of this, the United States passed the Federal Analog Act in 1986. This bill banned the production of any chemical analogue of a Schedule I or Schedule II substance that has substantially similar pharmacological effects, with the intent of human consumption.
- Derivative (chemistry)
- Homolog, a compound of a series differing only by repeated units
- Functional analog, compounds with similar physical, chemical, biochemical, or pharmacological properties
- Transition state analog
- Federal Analogue Act, a United States bill banning chemical analogues of illegal drugs
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- Analoging in ChEMBL, DrugBank and the Connectivity Map — a free web-service for finding structural analogs in ChEMBL, DrugBank and the Connectivity Map.
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