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Andhra Ikshvakus were one of the earliest recorded ruling dynasties of the Krishna-Guntur regions of Andhra Pradesh.They ruled the eastern Andhra country along the Krishna river during the later half of the 2nd century CE.  Their capital was Vijayapuri (Nagarjunakonda). It is a strong common belief that Andhra Ikshvakus were related to the mythological Ikshvakus, although Andhra Ikshvakus seem to be a local tribe who adopted the title.
Archaeological evidence has suggested that the Andhra Ikshvakus immediately succeeded the Satavahanas in the Krishna river valley. Ikshvakus have left inscriptions at Nagarjunakonda, Jaggayyapeta, Amaravati and Bhattiprolu.
Andhra Ikshvakus were originally feudatories of the Satavahanas and bore the title Mahatalavara. Although the Puranas state that seven kings ruled for 100 years in total, the names of only four of them are known from inscriptions.
- Vasishthiputra Sri Santamula (Santamula I), the founder of the line, performed the Asvamedha, Agnihotra, Agnistoma and Vajapeya sacrifices. Santamula performed the Asvamedha sacrifices with a view to proclaiming their independent and imperial status. It had become a common practice among the rulers of the subsequent dynasties to perform the Asvamedha sacrifice in token of their declaration of independent status. From this fact, it can be inferred that it was Santamula I who first declared his independence and established the Andhra Ikshvaku dynasty.
- Virapurushadatta was the son and successor of Santamula through his wife Madhari. He had a sister named Adavi Santisri. He took a queen from the Saka family of Ujjain and gave his daughter in marriage to a Chutu prince. Almost all the royal ladies were Buddhists. An aunt of Virapurisadata built a big Stupa at Nagarjunikonda. Her example was followed by other women of the royal family.
- Virapurisadata's son Ehuvula Santamula (Santamula II) ruled after a short Abhira interregnum. His reign witnessed the completion of a Devi Vihara, the Sihala Vihara, a convent founded for the accommodation of Sinhalese monks, and the Chaitya-ghara (Chaitya hall) dedicated to the fraternities (Theriyas) of Tambapanni (Ceylon). Ceylonese Buddhism was in close touch with Andhra. The sculptures of Nagarjunakonda, which include large figures of Buddha, show decided traces of Greek influence and Mahayana tendencies.
- Rudrapurushadatta was the name of an Ikshvaku ruler found in inscriptions from Gurajala in Guntur districts of Andhra Pradesh. He could have been a son of Ehuvula Santamula. Rudrapurushadatta ruled for more than 11 years. He was probably the last important ruler of the Andhra Ikshvaku family. After him there were three more unknown rulers according to the Puranas. Around 278 CE, the Abhiras might have put an end to the Ikshvakus.
- The Andhras Through the Ages by Kandavalli Balendu Sekharam
- Andhra Ikshvaku inscriptions
- Ancient India, A History Textbook for Class XI, Ram Sharan Sharma, National Council of Educational Research and Training, India , pp 212