Peyser's first job in journalism after graduating from college was a temporary assignment for the Albany, New York, bureau of the Associated Press. She then moved to the West Virginia bureau, followed by a brief time at CNN, and then moved to The Tampa Tribune.
The Washington Post has described Peyser as an "object of fascination among some media observers in New York, who count her unforgiving, exuberantly spiteful columns as a guilty pleasure." New York magazine described her as "the Madame Defarge of the New York Post" in a 2004 profile.
She has written two books, "Mother Love, Deadly Love: The Susan Smith Murders'' (HarperCollins 1995); and "Celebutards: The Hollywood Hacks, Limousine Liberals and Pandering Politicians Who Are Destroying America (Kensington 2009)
Her column titled "The confessions of the Jogger 5 do not lie" appears in the Ken Burns documentary The Central Park Five. The convictions of the five juveniles who confessed in the 1989 Central Park jogger case were vacated after another man's confession was substantiated by DNA evidence.
In December 2013, Peyser was criticized for her commentary on the state funeral of Nelson Mandela. In her column, Peyser claimed that US President Barack Obama behaved like a "hormone-ravaged frat boy on a road trip to a strip bar". She concluded by saying that Obama "has some 'splaining to do", an expression of Ricky Ricardo from the I Love Lucy show.
In October 2001, Peyser's employer, New York Post owner Rupert Murdoch, offered a rare personal apology over Peyser's reference to CNN correspondent Christiane Amanpour in a September 21 column as a “CNN war slut”.
Peyser's parents, Austrian-born Ruth (née Sophie Staendig) and German-born mathematician Gideon Peyser, met while serving in the Israeli army. They settled in New York City in the 1950s. Peyser grew up in Queens, and graduated from Bayside High School. She attended the State University of New York at New Paltz and at Albany.
- Biography - AndreaPeyser.com, Retrieved June 8, 2011 (most facts in biography are also related in news articles)
- Eaton, Phoebe (26 April 2004). The Madame Defarge of the New York Post, New York (magazine), Retrieved June 8, 2011
- Horowitz, Jason (7 June 2011). New York Post columnist spares none when politicians fall from grace, Washington Post
- Testerman, Jeff (12 April 1992). Media firestorm, St. Petersburg Times ("For the Mets, the last straw was the reporting of New York Post columnist Andrea Peyser ...")
- Peyser, Andrea (December 6, 2002). "The confessions of the Jogger 5 do not lie". New York Post. Retrieved January 5, 2014.
- Gay, Jason. "Murdoch Apologizes to Amanpour". The New York Observer. Retrieved 13 December 2013.
- Post Staff Report. "Andrea Peyser’s mother dies". New York Post. Retrieved 13 December 2013.