Andrew Bruce Holmes
|Andrew Bruce Holmes|
5 September 1943 |
|Nationality||Australian and British|
|Institutions||CSIRO, University of Melbourne, Imperial College London|
|Alma mater||University of Melbourne, BSc; University College London, PhD|
|Doctoral advisor||Franz Sondheimer|
|Other academic advisors||Albert Eschenmoser (postdoctoral)|
|Known for||Natural product synthesis, Organic electronics|
Andrew Bruce Holmes, AM FRS FAA FinstP (born 5 September 1943) is an Australian and British senior research chemist and professor at the Bio21 Institute, Melbourne, Australia. His research interests lie in the synthesis of biologically-active natural products (spanning therapeutic materials to new biotechnological probes) and optoelectronic polymers (with applications to electroluminescent flexible displays and organic solar cells).
Andrew Holmes' undergraduate studies and masters' research were conducted at the University of Melbourne in Australia. Travelling to the UK on a Shell Overseas Science Scholarship, he performed his PhD work at University College London under the supervision of Franz Sondheimer.
As a postdoctoral researcher, Holmes worked on the total synthesis of Vitamin B12 with Albert Eschenmoser. In 1972 he was appointed as a demonstrator to the University of Cambridge where he stayed for 32 years, ultimately as Professor of Organic and Polymer Chemistry, and Director of the Melville Laboratory for Polymer Synthesis where he oversaw the founding and initial decade of the Melville Laboratory.
Holmes' early work at Cambridge expanded his interest in new techniques for synthesising small molecules that are biologically-active and practically-useful, including natural products (such as alkaloids) and peptidomimetics. In 1989, during systematic characterisation of a newly synthesised conductive polymer, Chloe Jennings working in Holmes' research group observed that the polymer emitted light when a current was passed through it. An intensive period of research in Holmes' group, and other polymer chemistry groups, led to the discovery of differently-coloured light-emitting polymers that spanned the visible colour spectrum. A subsequent collaboration with physicist Richard Friend and co-workers at Cambridge's Cavendish Laboratory revealed the potential of these conjugated polymers for applications such as organic LEDs and rollable displays. Friend and Holmes co-founded the company Cambridge Display Technologies for commercial exploitation of these materials – an early success story of Silicon Fen.
In 2004 Holmes returned to his native Australia on a Federation Fellowship, to lead a group at the newly established Bio21 Institute. He has pursued the application of photovoltaic polymers to solar energy, and was instrumental in forming the Victorian Organic Solar Cell Consortium. He has also continued to develop new syntheses of novel, biologically-useful materials. An example is his groups' synthesis of phosphoinositides, amphiphilic phospholipids situated in the cell membrane, which collaborators at the Ludwig Institute for Cancer Research have used to probe the dynamics of signal transduction (intercellular signaling being an important component of many aspects of cell biology, including that of tumors).
Holmes has served on the editorial or advisory boards of numerous learned scientific journals, including Organic Letters, Chemical Communications and Angewandte Chemie. In 2006, his 1998 paper on electroluminescent polymers was the most highly cited paper in Angewandte Chemie's 120-year history. He was elected Fellow of the Royal Society in 2000, and Fellow of the Australian Academy of Science in 2006. In 2003, he received the Descartes Prize and in 2012 the Royal Medal of the Royal Society. His formal titles include Chemistry alumnus, Laureate Professor of Chemistry, University of Melbourne; CSIRO Fellow, CSIRO Division of Materials Science and Engineering; Emeritus Professor and Distinguished Research Fellow, Imperial College London; Fellow of the Royal Society; Fellow of the Australian Academy of Science; Fellow of the Australian Academy of Technological Sciences and Engineering; and Foreign Secretary of the Australian Academy of Science. In 2004 he was appointed Member of the Order of Australia "For service to science through research and development, particularly in the fields of organic synthesis and polymer chemistry." By August 2012 he had authored over 490 scientific papers and 52 patent applications.
Holmes is a keen hillwalker and an enthusiastic aficionado of classical music, from baroque to romantic opera. During his time in Cambridge he was a member and regular volunteer at St. Columba's United Reformed Church. He lives in Melbourne and Lorne, Victoria with his wife Jennifer.
- A. Holmes, H. Maag, N. Obata, P. Schneider, W. Schilling, J. Schreiber, and A. Eschenmoser (1972). "Total Synthese von Vitamin B12". Chimia 26 (320).
- Melville Laboratory for Polymer Synthesis
- J.H. Burroughes; D.D.C. Bradley, A.R. Brown, R.N. Marks, K. MacKay, R.H. Friend, P.L. Burns, and A.B. Holmes (1990). "Light-emitting diodes based on conjugated polymers". Nature 347: 539–541. doi:10.1038/347539a0. Retrieved 2012-08-22.
- Cambridge Display Technologies
- Conway, S. J.; Gardiner, J.; Grove, S. J. A.; Johns, M. K.; Lim, Z. Y.; Painter, G. F.; Robinson, D. E. J. E.; Schieber, C.; Thuring, J. W.; Wong, L. S. -M.; Yin, M. X.; Burgess, A. W.; Catimel, B.; Hawkins, P. T.; Ktistakis, N. T.; Stephens, L. R.; Holmes, A. B. (2010). "Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes". Organic & Biomolecular Chemistry 8 (1): 66–76. doi:10.1039/b913399b. PMID 20024134.
- Kraft A, Grimsdale AC, Holmes AB (2 March 1998). "Electroluminescent Conjugated Polymers - Seeing Polymers in a New Light". Angewandte Chemie International Edition 37 (4): 402–428. doi:10.1002/(SICI)1521-3773(19980302)37:4<402::AID-ANIE402>3.0.CO;2-9. ISSN 1433-7851.
- Thomson ISI, 3/8/2006
- Member of the Order of Australia (AM), 26 January 2004, It's an Honour.
- Margaret Throsby interviews Andrew Holmes, ABC Radio's Midday Program, 8 August 2012, www.abc.net.au/classic
- List of Royal Society Medalists, 2012 (see also the Royal Medal)
- Andrew Holmes' group website at the University of Melbourne
- Andrew Holmes' biographical page at the University of Melbourne
- Andrew Holmes' biographical sketch at the Royal Society website
- Victorian Organic Solar Cells Consortium
- CSIRO press release: "Australian scientist awarded a Royal Medal from the Royal Society London", July 10, 2012
- Robyn Williams interviews Andrew Holmes for ABC Radio's The Science Show: "The value of international scientific collaborations", May 5, 2012 (transcript and audio file available for download at link)