Andrew Lumsden (scientist)

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This article is about the scientist. For the choral director, see Andrew Lumsden (choral director).
Andrew Lumsden
Andrew lumsden.jpg
Andrew Lumsden
Nationality English
Fields Neurobiology
Institutions MRC Centre for Developmental Neurobiology, King's College London
Guy’s Hospital Medical School
University of California, Berkeley
Alma mater University of Cambridge, University of London

Andrew Lumsden FRS FMedSci is an English neurobiologist, Professor of the University of London and founder in 2000 of the Medical Research Council Centre for Developmental Neurobiology[1] at King's College London. He is a Fellow of the Royal Society, the Academy of Medical Sciences, and King’s College London, and a member of the European Molecular Biology Organization.

Andrew Lumsden attended Kingswood School, Bath (as Andrew Sita-Lumsden) and graduated from St. Catharine's College in the University of Cambridge with Double First Class Honours in Natural Sciences. After visiting Yale University for two years as a Fulbright Scholar, he returned to England to complete his PhD in Developmental Biology at the University of London. He has held various lectureships at Guy’s Hospital Medical School and the United Medical Schools of Guy’s and St. Thomas’ Hospital before being made a full Professor of the University of London in 1989. He has been an International Scholar of the Howard Hughes Medical Institute (1993–1998) and a Miller Institute visiting Professor at the University of California, Berkeley (1994).

Lumsden has served on the Medical Research Council Neurosciences and Mental Health Board and Grants Committee (1992—1998), the Wellcome Trust Neuroscience Funding Committee (1997—2000), and the Brain Functions Grant Review Committee of the Human Frontier Science Program (1998—2001). He has also served as editor of Development[2] (1995—2007) and is co-founder of the on-line, open-access journal Neural Development.[3] In addition, Andrew Lumsden is a co-Head of Section for Faculty of 1000.[4]

Andrew Lumsden has co-authored a book entitled The Developing Brain with Michael Brown and Roger Keynes[5]

Research[edit]

Following his PhD on epithelial-mesenchymal interactions in mammalian development, Lumsden’s interest moved to the question of how integumental structures, such as teeth and vibrissae acquire their nerve supply, and how the cranial neural crest contributes to their patterning. Studies on the development of the trigeminal nerve and ganglion led on to observations of the organisation of their corresponding motor and sensory regions of the central nervous system. His seminal observations and experiments on the developing hindbrain of mammal and bird embryos confirmed the long suggested but never agreed view that this brain region has a rigidly segmented organisation, much like the body plan of insects and worms. To assist his research, he developed the Lumsden BioScissors.[6] Most recently, he has focussed on the developing forebrain, where he discovered signalling properties in a small set of cells that pattern the large surrounding region of the thalamus.

Awards[edit]

Fellowship of the Royal Society (elected 1994), the Academy of Medical Sciences (1998), and King's College London (1999), and membership of the European Molecular Biology Organization (EMBO, 2008).

In 2001, he was awarded The Royal Society’s Prize for Neuroscience (The Ferrier Lecture[7]), and in 2007, the W. Maxwell Cowan Prize[8] for "outstanding contributions in developmental neuroscience".

Lumsden has also been elected Freeman of the Worshipful Company of Clockmakers in 2006.

Major publications[edit]

  • Lumsden AG, Davies AM (1983). "Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor". Nature 306 (5945): 786–8. doi:10.1038/306786a0. PMID 6656880. 
  • Lumsden AG, Davies AM (1986). "Chemotropic effect of specific target epithelium in the developing mammalian nervous system". Nature 323 (6088): 538–9. doi:10.1038/323538a0. PMID 3762707. 
  • Tessier-Lavigne M, Placzek M, Lumsden AG, Dodd J, Jessell TM (1988). "Chemotropic guidance of developing axons in the mammalian central nervous system". Nature 336 (6201): 775–8. doi:10.1038/336775a0. PMID 3205306. 
  • Lumsden A (March 1989). "Multipotent cells in the avian neural crest". Trends Neurosci. 12 (3): 81–3. doi:10.1016/0166-2236(89)90159-8. PMID 2469219. 
  • Lumsden A, Keynes R (February 1989). "Segmental patterns of neuronal development in the chick hindbrain". Nature 337 (6206): 424–8. doi:10.1038/337424a0. PMID 2644541. 
  • Heffner CD, Lumsden AG, O'Leary DD (January 1990). "Target control of collateral extension and directional axon growth in the mammalian brain". Science 247 (4939): 217–20. doi:10.1126/science.2294603. PMID 2294603. 
  • Fraser S, Keynes R, Lumsden A (March 1990). "Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions". Nature 344 (6265): 431–5. doi:10.1038/344431a0. PMID 2320110. 
  • Lumsden A (August 1990). "The cellular basis of segmentation in the developing hindbrain". Trends Neurosci. 13 (8): 329–35. doi:10.1016/0166-2236(90)90144-Y. PMID 1699318. 
  • Lumsden A, Sprawson N, Graham A (December 1991). "Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo". Development 113 (4): 1281–91. PMID 1811942. 
  • Guthrie S, Muchamore I, Kuroiwa A, Marshall H, Krumlauf R, Lumsden A (March 1992). "Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions". Nature 356 (6365): 157–9. doi:10.1038/356157a0. PMID 1545869. 
  • Simon H, Lumsden A (August 1993). "Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline". Neuron 11 (2): 209–20. doi:10.1016/0896-6273(93)90179-U. PMID 8394719. 
  • Lumsden A, Clarke JD, Keynes R, Fraser S (June 1994). "Early phenotypic choices by neuronal precursors, revealed by clonal analysis of the chick embryo hindbrain". Development 120 (6): 1581–9. PMID 8050364. 
  • Graham A, Francis-West P, Brickell P, Lumsden A (December 1994). "The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest". Nature 372 (6507): 684–6. doi:10.1038/372684a0. PMID 7990961. 
  • Logan C, Wizenmann A, Drescher U, Monschau B, Bonhoeffer F, Lumsden A (1996). "Rostral optic tectum adopts a caudal phenotype following ectopic Engrailed expression". Current Biology 6 (8): 1006–1014. doi:10.1016/S0960-9822(02)00645-0. PMID 8805331. 
  • Lumsden A, Krumlauf R (1996). "Patterning the vertebrate neuraxis". Science 274 (5290): 1109–1115. doi:10.1126/science.274.5290.1109. PMID 8895453. 
  • Studer M, Lumsden A, Ariza-McNaughton L, Bradley A, Krumlauf R (1996). "Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1". Nature 384 (6610): 630–634. doi:10.1038/384630a0. PMID 8967950. 
  • Bell E, Wingate, R. Lumsden A (1999). "Homeotic transformation of rhombomere identity following localised Hoxb1 misexpression". Science 284 (5423): 2168–2171. doi:10.1126/science.284.5423.2168. PMID 10381880. 
  • Fortin G, Jungbluth S, Lumsden A, Champagnat J (1999). "Segmental specification of GABAergic inhibition during development of hindbrain neural networks". Nature Neuroscience 2 (10): 873–877. doi:10.1038/13172. PMID 10491606. 
  • Zeltser L, Larsen C, Lumsden A (2001). "A new developmental compartment in the forebrain regulated by Lunatic fringe". Nature Neuroscience 4 (7): 683–684. doi:10.1038/89455. PMID 11426219. 
  • Larsen C, Zeltser L, Lumsden A (2001). "Boundary formation and compartition in the avian diencephalon". Journal of Neuroscience 21 (13): 4699–4711. PMID 11425897. 
  • Matsumoto K, Nishihara S, Kamimura M, Shiraishi T, Otoguro T, Uehara M, Maeda Y, Ogura K, Lumsden A, Ogura T (2004). "The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation". Nature Neuroscience 7 (6): 605–612. doi:10.1038/nn1249. PMID 15133517. 
  • Kiecker C, Lumsden A (2004). "Hedgehog signalling from the zona limitans intrathalamica regulates the emergence of thalamic and prethalamic identity". Nature Neuroscience 7 (11): 1242–1249. doi:10.1038/nn1338. PMID 15494730. 
  • Kiecker C, Lumsden A (2005). "Compartments and their boundaries in vertebrate brain development". Nature Reviews Neuroscience 6 (7): 553–564. doi:10.1038/nrn1702. PMID 15959467. 
  • Scholpp S, Delogu A, Gilthorpe J, Peukert D, Lumsden A (2009). "Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus". Proceedings of the National Academy of Sciences of the United States of America 106 (47): 19895–19900. doi:10.1073/pnas.0910894106. PMC 2775703. PMID 19903880. 
  • Scholpp S, Lumsden A (2010). "Building a bridal chamber: development of the thalamus". Trends in Neurosciences 33 (8): 373–380. doi:10.1016/j.tins.2010.05.003. PMC 2954313. PMID 20541814. 
  • Delogu A, Sellers K, Zagoraiou L, Bocianowska-Zbrog A, Mandal S, Guimera J, Rubenstein JL, Sugden D, Jessell T, Lumsden A (2012). "Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms". Neuron 75 (4): 648–662. doi:10.1016/j.neuron.2012.06.013. PMID 22920256. 
  • Gilthorpe JD, Oozeer F, Nash J, Calvo M, Bennett DL, Lumsden A, Pini A (2013). "Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia". F1000Research 1: 148. doi:10.12688/f1000research.2-148. PMC 3782347. PMID 24358859. 

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