Androgen-binding protein

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Androgen-binding protein, Sex hormone-binding globulin
Identifiers
Symbol SHBG
Alt. symbols ABP
Entrez 6462
HUGO 10839
OMIM 182205
RefSeq NM_001040
UniProt P04278
Other data
Locus Chr. 17 p13-p12

Androgen-binding protein (ABP) is a glycoprotein (beta-globulin) produced by the Sertoli cells in the seminiferous tubules of the testis that binds specifically to testosterone (T), dihydrotestosterone (DHT), and 17-beta-estradiol.

Because ABP binds to T and DHT, these hormones are made less lipophilic and become concentrated within the luminal fluid of the seminiferous tubules. The higher levels of these hormones enable spermatogenesis in the seminiferous tubules and sperm maturation in the epididymis.

ABP has the same amino acid sequence as sex hormone-binding globulin (SHBG); the difference is the site of production and the addition of different sugar moieties. ABP contains 403 amino acids, resulting in a molecular weight of 44,533. Its gene is located on chromosome 17.

ABP’s production is regulated under influence of FSH on Sertoli cell, enhanced by insulin, retinol, and testosterone.

ABP may also be secreted in other organs; for instance, mice produce a salivary ABP.

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