Hyperandrogenism

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Hyperandrogenism, or androgen excess, is a medical condition characterized by excessive levels of androgens in the body.

Hyperandrogenism is one of the primary symptoms of polycystic ovary syndrome (PCOS). In such cases, it presents with symptoms such as acne and seborrhea, is frequent in adolescent girls and is often associated with irregular menstrual cycles. In most instances, these symptoms are transient and reflect only the immaturity of the hypothalamic-pituitary-ovarian axis during the first years following menarche.[1] Approximately three-quarters of patients with PCOS (by the diagnostic criteria of NIH/NICHD 1990) have evidence of hyperandrogenism, with free testosterone being the single most predictive marker with ~60% of patients demonstrating supranormal levels.[2] Hyperandrogenism can also be the result of excessive production of adrenal androgens caused by various conditions of hyperactivity of the adrenal glands.

In women, signs and symptoms of hyperandrogenism frequently include acne, scalp hair loss (androgenic alopecia), excessive facial and body hair (hirsutism), high libido, and others. Collectively, these symptoms are described as virilization.

Management of hyperandrogenism symptoms like androgenic alopecia, include the use of antiandrogens such as cyproterone acetate, spironolactone, and flutamide. [Tosti A, Camacho-Martinez F, Dawber R. Management of androgenetic alopecia. J Eur Acad Dermatol Venereol. 1999 May;12(3):205-14], [Diamanti-Kandarakis E. Current aspects of antiandrogen therapy in women. Curr Pharm Des. 1999;5(9):707-23],[Sinclair R, Wewerinke M, Jolley D.Treatment of female pattern hair loss with oral antiandrogens. Br J Dermatol. 2005 Mar;152(3):466-73], [Vierhapper H, Maier H, Nowotny P, Waldhäusl W. Production rates of testosterone and of dihydrotestosterone in female pattern hair loss. Metabolism. 2003 Jul;52(7):927-9].

Sports[edit]

In Sports and Games,a female player is not eligible to participate in female category if the amount of Androgenic hormone exceeds the permissible limits, as this could present an unfair advantage. [3] [4]

See also[edit]

References[edit]

  1. ^ Christine Cortet-Rudelli, Didier Dewailly (Sep 21, 2006). "Diagnosis of Hyperandrogenism in Female Adolescents". Hyperandrogenism in Adolescent Girls. Armenian Health Network, Health.am. Retrieved 2006-11-21. 
  2. ^ Huang A, Brennan K, Azziz R (April 2010). "Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by the National Institutes of Health 1990 criteria". Fertil. Steril. 93 (6): 1938–41. doi:10.1016/j.fertnstert.2008.12.138. PMC 2859983. PMID 19249030. 
  3. ^ http://pib.nic.in/newsite/PrintRelease.aspx?relid=94015
  4. ^ http://pib.nic.in/archieve/others/2013/mar/d2013032001.pdf