Brown-Burke started her political career as a Corporate Area Councillor of the Kingston and Saint Andrew Corporation. She was elected a vice-president of the People's National Party in 2006 along with Fenton Ferguson, Derrick Kellier, and Peter Phillips, beating out Sharon Hay-Webster, Louis Moyston, and Kern Spencer. She moved from local to national politics in January 2012 with her appointment as Deputy President of the Senate of Jamaica after Portia Simpson Miller came to power in the December 2011 general election. After the PNP's victory over the Jamaica Labour Party (JLP) in the March 2012 election, she became mayor of Kingston.
In May 2013, Brown-Burke tweeted denunciations of Television Jamaica's All Angles and CVM TV's Direct for respectively inviting JLP leader Andrew Holness and opposition spokesman on finance and planning Audley Shaw as guests, without including PNP members for balance. She was criticised for her use of the minced oath "What the F", and apologised for her language and deleted the tweet while defending the views she had expressed.
Brown-Burke is married to Paul Burke, a former Region Three Chairman of the PNP who also ran for PNP vice-president in 2004. Brown-Burke moved to the United States in 1986. She naturalised as a United States citizen in 1995, but decided to move back to Jamaica two years later. She renounced her U.S. citizenship in January 2012 after she was appointed to the Senate, and received her Certificate of Loss of Nationality in early February.
- "Government Names All 13 Senators". The Jamaica Gleaner. 16 January 2012. Retrieved 4 November 2012.
- Virtue, Erica (24 September 2006). "Brown-Burke now a PNP vice-president". The Jamaica Observer. Retrieved 4 November 2012.
- Luton, Daraine (18 January 2012). "Brown-Burke: I Renounced US Citizenship". The Jamaica Gleaner. Retrieved 4 November 2012.
- "Angela Brown Burke is now Mayor". RJR News. 2 April 2012. Retrieved 4 November 2012.
- Johnson, Jovan (2 May 2013). "Mayor Burke Says Sorry For 'F' Tweet". The Jamaica Gleaner. Retrieved 11 May 2013.
- "Mayor Brown Burke apologises for offensive tweet". The Jamaica Observer. 2 May 2013. Retrieved 11 May 2013.
- Dunkley, Alicia (12 February 2012). "Brown-Burke offers proof". The Jamaica Observer. Retrieved 4 November 2012.