She began her acting career in 1993 at Second City Detroit. She was introduced to Frances Callier in Chicago, and the pair would later become Frangela, creating the animated TV series, Hey Monie!, which appeared on BET and Oxygen and won a NAMIC award. The duo perform stand up comedy together have appeared in an ad for the Equality Campaign's "NO on Prop 8" campaign. Shelton and Callier worked on the British comedy series 3 Non-Blondes. Shelton appears regularly as Frangela on VH1sBest Week Ever. The duo recently finished their hit show An Evening with the Afro-Saxons. The duo also host a radio talk show together on KEIB on Saturday afternoons.
Shelton was an original cast member of the Second City Detroit comedy troupe, which opened on September 15, 1993. Other notable cast members included Larry Joe Campbell and Keegan-Michael Key.