Angiopoietin-related protein 1

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Angiopoietin-like 1
Identifiers
Symbols ANGPTL1 ; ANG3; ANGPT3; ARP1; AngY; UNQ162; dJ595C2.2
External IDs OMIM603874 MGI1919963 HomoloGene128467 GeneCards: ANGPTL1 Gene
Orthologs
Species Human Mouse
Entrez 9068 72713
Ensembl ENSG00000116194 ENSMUSG00000033544
UniProt O95841 Q640P2
RefSeq (mRNA) NM_004673 NM_028333
RefSeq (protein) NP_004664 NP_082609
Location (UCSC) Chr 1:
178.82 – 178.84 Mb
Chr 1:
156.84 – 156.86 Mb
PubMed search [1] [2]

Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene.[1][2][3]

Function[edit]

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.[3]

References[edit]

  1. ^ Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett 443 (3): 353–6. doi:10.1016/S0014-5793(99)00008-3. PMID 10025962. 
  2. ^ Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704. 
  3. ^ a b "Entrez Gene: ANGPTL1 angiopoietin-like 1". 

Further reading[edit]