Angiotensin-converting enzyme 2

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Angiotensin I converting enzyme 2
Protein ACE2 PDB 1r42.png
PDB rendering based on 1r42.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACE2 ; ACEH
External IDs OMIM300335 MGI1917258 HomoloGene41448 ChEMBL: 3736 GeneCards: ACE2 Gene
EC number 3.4.17.23
RNA expression pattern
PBB GE ACE2 219962 at tn.png
PBB GE ACE2 222257 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 59272 70008
Ensembl ENSG00000130234 ENSMUSG00000015405
UniProt Q9BYF1 Q8R0I0
RefSeq (mRNA) NM_021804 NM_001130513
RefSeq (protein) NP_068576 NP_001123985
Location (UCSC) Chr X:
15.58 – 15.62 Mb
Chr X:
164.14 – 164.19 Mb
PubMed search [1] [2]

AngiotensinI-converting enzyme 2 (ACE 2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9],[1] or the conversion of angiotensin II to angiotensin 1-7.[2] ACE 2 has direct effects on cardiac functiona, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.[3]

ACE 2 is the receptor for SARS virus.[4]

See also[edit]

References[edit]

  1. ^ Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S (2000). "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9". Circ. Res. 87 (5): E1–9. PMID 10969042. 
  2. ^ Keidar S, Kaplan M, Gamliel-Lazarovich A (2007). [_ http://cardiovascres.oxfordjournals.org/cgi/content/full/73/3/463 "ACE2 of the heart: From angiotensin I to angiotensin (1-7)"]. Cardiovasc Res. 73 (3): 463–9. doi:10.1016/j.cardiores.2006.09.006. PMID 17049503. 
  3. ^ Boehm M, Nabel EG (2002). "Angiotensin-converting enzyme 2--a new cardiac regulator". N. Engl. J. Med. 347 (22): 1795–7. doi:10.1056/NEJMcibr022472. PMID 12456857. 
  4. ^ Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., ... & Penninger, J. M. (2005). A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury. Nature medicine, 11(8), 875-879. doi:10.1038/nm1267

Further reading[edit]