There are only three settlements on Angistri - Milos (Megalochori), Skala and Limenaria. Milos (pop. 566) is the main village where the majority of the Greek population of the island lives. Skala (pop. 448) is a twenty-minute walk from Milos along the coastal road. Skala is where most of the tourist facilities and hotels are. Limenaria (pop. 128) is a very small village on the other side of the island with very little tourism. The island's population is 1,142 inhabitants according to the 2011 Greek census. Its land area is 13.367 km2 (5.161 sq mi).
Angistri is very close to the larger Saronic island of Aegina. The island can be reached from Aegina by a number of boats in just ten minutes. These boats include the Angistri Express and a number of small "water taxis". The island is also an hour's boat ride from the large Athenian port of Piraeus.