A commercial and light industrial area, the district includes properties along Ann Street from Chapel Street South to Hicks Street. It also includes properties east of Ann Street fronting Pearl Street and Hicks Street to roughly Haynes Street, as well as properties west of Ann Street fronting Allyn and Asylum Streets to roughly a third of the block. The district is primarily composed of 19th-century brick mercantile buildings and contains 22 contributing and 3 non-contributing properties.
Within the district are the former Sport and Medical Science Academy building (a non-contributing property), and the Central Fire Station of the Hartford Fire Department. The district includes location of the Hartford Steam Company generating plant. Other contributing properties in the district include St. Patrick's Church (built in 1876), the Masonic Temple (built in 1894), Daly Electrical (316-320 Ann Street), and the Hotel Lenox (also known as Hartford Hotel), a Beaux-Arts eclectic style building at 280-294 Ann Street, built in 1899.
In 2008, Ann Street was renamed "Ann Uccello Street" in honor of Ann Uccello, Hartford's first female mayor.