Anna Karenina principle
The Anna Karenina principle describes an endeavor in which a deficiency in any one of a number of factors dooms it to failure. Consequently, a successful endeavor (subject to this principle) is one where every possible deficiency has been avoided.
Happy families are all alike; every unhappy family is unhappy in its own way.
In statistics, the term Anna Karenina principle is used to describe significance tests: there are any number of ways in which a dataset may violate the null hypothesis and only one in which all the assumptions are satisfied.
Example: failed domestication 
The Anna Karenina principle was popularized by Jared Diamond in his book Guns, Germs and Steel. Diamond uses this principle to illustrate why so few wild animals have been successfully domesticated throughout history, as a deficiency in any one of a great number of factors can render a species undomesticable. Therefore all successfully domesticated species are not so because of a particular positive trait, but because of a lack of any number of possible negative traits.
From chapter 9 of Guns, Germs and Steel, six groups of reasons for failed domestication of animals are:
- Diet - To be a candidate for domestication, a species must be easy to feed. Finicky eaters make poor candidates. Non-finicky omnivores make best candidates.
- Growth Rate - The animal must grow fast enough to be economically feasible. Elephant farmers, for example, would wait perhaps 12 years for their herd to reach adult size.
- Problems of Captive Breeding - The species must breed well in captivity. Species having mating rituals prohibiting breeding in a farm-like environment make poor candidates for domestication. These rituals could include the need for privacy or long, protracted mating chases.
- Nasty Disposition - Some species are too mean and nasty to be good candidates for domestication. Farmers must not be at risk of life or injury every time they enter the animal pen. The zebra is of special note in the book, as it was recognized by local cultures and Europeans alike as extremely valuable and useful to domesticate, but it proved impossible to tame. Horses in Africa proved to be susceptible to disease and attack by a wide variety of animals, while the very characteristics that made the zebra hardy and survivable in the harsh environment of Africa also made it fiercely independent.
- Tendency to Panic - Species are genetically predisposed to react to danger in different ways. A species that immediately takes flight is a poor candidate for domestication. A species that freezes, or mingles with the herd for cover in the face of danger, is a good candidate. Deer in North America have proven almost impossible to domesticate and have difficulty breeding in captivity. Horses, however, immediately thrived from the time they were introduced to North America in the 17th century.
- Social Structure - Species of lone, independent animals make poor candidates. A species that has a strong, well defined social hierarchy is more likely to be domesticated. A species that can imprint on a human as the head of the hierarchy is best. Different social groups must also be tolerant of one another.
Ecological risk assessment 
Moore describes applications of the Anna Karenina principle in ecology:
Successful ecological risk assessments are all alike; every unsuccessful ecological risk assessment fails in its own way. Tolstoy posited a similar analogy in his novel Anna Karenina : "Happy families are all alike; every unhappy family is unhappy in its own way." By that, Tolstoy meant that for a marriage to be happy, it had to succeed in several key aspects. Failure on even one of these aspects, and the marriage is doomed . . . the Anna Karenina principle also applies to ecological risk assessments involving multiple stressors.
Aristotle's version 
Again, it is possible to fail in many ways (for evil belongs to the class of the unlimited, as the Pythagoreans conjectured, and good to that of the limited), while to succeed is possible only in one way (for which reason also one is easy and the other difficult -- to miss the mark easy, to hit it difficult); for these reasons also, then, excess and defect are characteristic of vice, and the mean of virtue; For men are good in but one way, but bad in many.
See also 
After a failed attempt to assassinate the British prime minister, Margaret Thatcher, the IRA said: "Today we were unlucky, but remember we only have to be lucky once. You will have to be lucky always."
Order in chaos of maladaptation 
Many experiments and observations of groups of humans, animals, trees, grassy plants, stockmarket prices, and changes in the banking sector proved the modified Anna Karenina principle.
By studying the dynamics of correlation and variance in many systems facing external, or environmental, factors, we can typically, even before obvious symptoms of crisis appear, predict when one might occur, as correlation between individuals increases, and, at the same time, variance (and volatility) goes up. ... All well-adapted systems are alike, all non-adapted systems experience maladaptation in their own way,... But in the chaos of maladaptation, there is an order. It seems, paradoxically, that as systems become more different they actually become more correlated within limits.
This effect is proved for many systems: from the adaptation of healthy people to a change in climate conditions to the analysis of fatal outcomes in oncological and cardiological clinics. The same effect is found in the stock market.
General mathematical backgrounds 
Vladimir Arnold in his book "Catastrophe Theory" describes "The Principle of Fragility of Good Things" which in a sense supplements the Principle of Anna Karenina: "good" systems must meet simultaneously a number of requirements; therefore, they are more fragile:
... for systems belonging to the singular part of the stability boundary a small change of the parameters is more likely to the send the system into the unstable region than into the stable region. This is a manifestation of a general principle stating that all good things (e.g. stability) are more fragile than bad things. It seems that in good situations a number of requirements must hold simultaneously, while to call a situation bad even one failure suffices.
- Diamond, J. (March 1997). Guns, Germs, and Steel: The Fates of Human Societies. W.W. Norton & Company. ISBN 0-393-03891-2.
- D.R.J. Moore. "The Anna Karenina Principle Applied to Ecological Risk Assessments of Multiple Stressors". Human and Ecological Risk Assessment, Volume 7, Number 2 (2001), pp. 231–237(7).
- Aristotle. Nicomachean Ethics, Translated by W. D. Ross, Oxford University Press, Oxford; Revised edition (11 Jun 2009)
- Anna Karenina principle explains bodily stress and stockmarket crashes, University of Leicester, 2010
- A.N. Gorban, E.V. Smirnova, T.A. Tyukina, Correlations, Risk and Crisis: From Physiology to Finance, Physica A, Vol. 389, Issue 16, 2010, pp 3193-3217.
- V.I. Arnol'd. "Catastrophe Theory", Springer-Verlag; 3 Rev Exp edition (September 1992), pp. 31–32. ISBN 3-540-54811-4