Anna and William Louis were married just after Anna's twenty fourth birthday on November 25, 1587. The marriage was however only a short one, Anna died only six months after the marriage; therefore, they had no children and William Louis never remarried. William Louis became Count of Nassau- Dillenburg.
Anna's mother, Anna of Saxony never had a happy marriage with Anna's father, William the Silent. Anna of Saxony was described as unstable and violent. She was unpopular with her family and the citizens.
Anna of Saxony took up with her lawyer, with whom she had an illegitimate daughter called Christina. After this incident, Anna and her siblings never saw their mother again. Anna of Saxony was sent to Beilstein castle with Christina, here her behavior became worse, until the servants were ordered to keep all knives away from her, lest she attack someone. Anna of Saxony began to suffer from hallucinations and violent outbursts. Christina was removed from her care and sent to be raised with her Anna and her siblings. William annulled their marriage, and remarried twice. Anna lived out the rest of her days in Dresden, until her death aged thirty-two in 1577.