At 19, Annette married jazz bassist Gary Peacock. At the beginning of the 60's she toured with Albert Ayler, studied Zen Macrobiotics with Michio Kushi, and was a close associate of Timothy Leary at the psychedelic center in Millbrook.
In 1964, pianist Paul Bley first began featuring her avant-garde compositions - ultimately on over 60 records. At the end of the 1960s she and Bley became strongly associated with the musical possibilities of the newly-emergent synthesizer. Given a prototype by Robert Moog Annette is thought to have been the first to use one to process her voice. As well as playing electric bass, elec. piano and elec. vibraphone - most notably at Town Hall, and a concert produced by Annette at Philharmonic Hall, Lincoln Center (NY) which she promoted with spots on late night TV and a guest appearance on The Tonight Show starring Johnny Carson.
In 1968 she recorded Revenge - its release thwarted by Polydor till 1972, and 1971 recorded I'm The One (voted by the journalists of WIRE magazine as one of the top 100 records that "set fire to the world") released by RCA in 1972; and appeared as a "Hologram" in a collaboration and show with Salvador Dalí. After which came the first gap of six years until her next release X-Dreams, when she was also recording with Allan Holdsworth on Bill Bruford's first solo project, the jazz fusion classic Feels Good to Me, followed by her next album "The Perfect Release", 1979.
She launched her own indie label ironicrecords in the UK with the single "Sky-skating", and issued four albums from 1981 to 1988 (see discography) distributed by Rough Trade.
Producer Manfred Eicher commissioned Annette in 1997 to compose a project for string quartet and herself on piano and voice. After 3 years of composing and arranging, and a recording silence of 12 years, An Acrobat's Heart was released in 2000 by ECM. This followed ECM's 1997 double CD tribute to Annette's 1964 - 1969 catalog of compositions: "Nothing Ever Was, Anyway - Music of Annette Peacock".
At the beginning of 2006, she started-up her own label again ironic US with an unpromoted release 31:31. At the same time the result of her collaboration with Coldcut, "Just for the Kick", was released on their current album Sound Mirrors distributed by Ninja Tune.
- Bley-Peacock Synthesizer Show: Revenge - "The Bigger the Love the Greater the Hate" (Polydor, 1968)
- I'm the One (RCA, 1972; CD release 2010 (ironic US)
- Annette & Paul Bley: Dual Unity (Freedom, 1972)
- Improvisie (America, 1972)
- X-Dreams (Aura UK, 1978)
- The Perfect Release (Aura UK, 1979)
- Sky-skating (ironicrecords, 1981)
- Been in the Streets Too Long (ironicrecords, 1983)
- I Have No Feelings (ironicrecords, 1986)
- Abstract-Contact (ironicrecords, 1988)
- An Acrobat's Heart (ECM, 2000)
- 31:31 (ironic US, 2006)
- The Collection (Aura UK, 1982)
- My Mama Never Taught Me How to Cook ... (The Aura Years 1978 - 1982) (Sanctuary, 2004)
- Don't Be Cruel / Dear Bela (Aura, 1978)
- Love's Out to Lunch / Rubber Hunger (Aura, 1979)
- Sky-skating / Taking It as It Comes (ironicrecords, 1981)
- Adler, David. "Annette Peacock: Biography". Allmusic. Retrieved 2011-01-09.
- Williamson, Don (2000-11-01). "An Acrobat's Heart". All About Jazz. Retrieved 2011-01-09.