Annexin A3

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Annexin A3
Protein ANXA3 PDB 1aii.png
PDB rendering based on 1aii.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ANXA3 ; ANX3
External IDs OMIM106490 MGI1201378 HomoloGene68445 GeneCards: ANXA3 Gene
EC number 3.1.4.43
RNA expression pattern
PBB GE ANXA3 209369 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 306 11745
Ensembl ENSG00000138772 ENSMUSG00000029484
UniProt P12429 O35639
RefSeq (mRNA) NM_005139 NM_013470
RefSeq (protein) NP_005130 NP_038498
Location (UCSC) Chr 4:
79.47 – 79.53 Mb
Chr 5:
96.79 – 96.85 Mb
PubMed search [1] [2]

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.[1][2]

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.[3]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.[2]

References[edit]

  1. ^ Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM (Aug 1991). "Chromosomal localization of the human annexin III (ANX3) gene". Genomics 10 (2): 441–8. doi:10.1016/0888-7543(91)90330-H. PMID 1830024. 
  2. ^ a b "Entrez Gene: ANXA3 annexin A3". 
  3. ^ Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID 18792929. 

Further reading[edit]