He became a doctor of both laws before becoming a cleric in Naples. In 1547, he was Neapolitan ambassador to Charles V, Holy Roman Emperor. Under Pope Paul III, he moved to Rome, becoming a protonotary apostolic participantium. The pope made him a domestic prelate of His Holiness on June 4, 1549. On June 6, 1549, he was named pro-legate in Bologna. He later became a referendary of the Apostolic Signatura. He was governor of Borgo in 1550.
On June 15, 1551, he was elected to be Archbishop of Avignon. He was governor of Borgo again in 1555. He joined the Apostolic Camera on February 28, 1556, later serving as its president under Pope Paul IV. On January 26, 1558, he was named governor of Civitavecchia. He resigned the government of the Archdiocese of Avignon in 1562.