In medicine before the 20th century, an anodyne was a drug that was believed to relieve or soothe pain by lessening the sensitivity of the brain or nervous system (Greek ἀνώδυνος anōdynos < ἀν- an- 'without' + ὀδύνη odynē 'pain'). It was essentially an analgesic.
Certain compound medicines were also called by this name, such as anodyne balsam, made of castile soap, camphor, saffron, and spirit of wine, and digested in a sand heat. It was recommended not only for easing extreme pain, but for assisting in discharging the peccant matter that occurred with the pain.
Literary use 
In literary usage, the word has escaped its strictly medical meaning to convey anything "soothing or relaxing" (so used since the 18th century) or even anything "non-contentious", "blandly agreeable", or unlikely to cause offence or debate.
See also 
- Richard Quain, A dictionary of medicine: including general pathology, general therapeutics, 1883 full text
- This article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). Encyclopædia Britannica (11th ed.). Cambridge University Press.
- This article incorporates text from a publication now in the public domain: Chambers, Ephraim, ed. (1728). "article name needed". Cyclopaedia, or an Universal Dictionary of Arts and Sciences (first ed.). James and John Knapton, et al.
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