She competed in the 2004 Summer Paralympics in Athens, Greece where she won silver medals in the T13 100m, T13 400m and F13 long jump. She also competed in the 2008 Summer Paralympics in Beijing, China. There she won a silver medal in the women's F13 long jump event and competed in the T13 100m and 200m events. In the 2012 Summer Paralympics she took the third place in F13 long jump, winning her fifth medal in the Paralympic Games. The Municipal Stadium "Anthi Karagianni" in her hometown of Kavala, Greece, was renamed in her honour in 2004.