Anti-histone antibodies

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Anti-histone antibodies are autoantibodies that are found in 50%-70% of patients with systemic lupus erythematosus (SLE) and in more than 95% of patients with drug-induced lupus erythematosus.[1] In other words, a test for anti-histone antibodies has a sensitivity of 50%-70% in detecting patients with SLE and more than 95% sensitivity in detecting patients with drug-induced LE.

An ELISA for detecting anti-histone antibodies is said to be positive when there is more than 25 units/ml anti-histone antibodies in a blood sample.[2]

References[edit]

  1. ^ Table 5-9 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.  8th edition.
  2. ^ chronolab.com > Autoantibodies associated with rheumatic diseases > Reference ranges Retrieved on April 29, 2010