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- In Western Maryland
- Battle of Antietam, a major American Civil War battle
- Antietam Creek, a tributary of the Potomac River in Pennsylvania and Maryland; source name for the battle
- Antietam, Maryland, an unincorporated community four miles south of the battlefield
- Antietam Iron Furnace Site and Antietam Village, listed on the NRHP in Maryland
- Antietam Hall, listed on the NRHP in Maryland
- In Pennsylvania
- Antietam Creek (Schuylkill River), a tributary of the Schuylkill River
- Antietam Lake, a reservoir in Berks County
- Antietam (band), US indie rock band
- USS Antietam, three US Navy ships
- Battleground 5: Antietam, a strategy computer game
- Sid Meier's Antietam!, a tactical computer game
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