Anthelmintic

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Anthelmintic effect of papain on Heligmosomoides bakeri.

Anthelmintics or antihelminthics are drugs that expel parasitic worms (helminths) from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges (those which stun) or vermicides (those which kill).

Pharmaceuticals[edit]

Anthelmintic resistance[edit]

The ability of worms to survive treatments that are generally effective at the recommended dose rate is considered a major threat to the future control of worm parasites of small ruminants and horses. This is especially true of nematodes and has contributed to the development of aminoacetonitrile derivatives for treatment against drug resistant nematodes.

The clinical definition of resistance is a 95% or less reduction in a "Fecal Egg Count" test.[clarification needed]

Treatment with an antihelminthic drug kills worms whose phenotype renders them susceptible to the drug. Worms that are resistant survive and pass on their "resistance" genes. Resistant worms accumulate and finally treatment failure occurs. See drug resistance.

References[edit]

Footnotes[edit]

General references[edit]

  • Department of the Army Headquarters (2004). U.S. Army Survival Manual Fm 21–76. Barnes & Noble Inc. ISBN 0-7607-4988-4. 

External links[edit]