An antiprogestogen, also called an antiprogesterone agent, or in the case of a synthetic compound, an antiprogestin, is a type of hormone antagonist in which that antagonizes or suppresses the actions of progesterone in the body, a sex hormone that plays a role in the menstrual cycle and pregnancy. Antiprogestogens may stop some cancer cells from growing and they are being studied in the treatment of breast cancer.
An example of an antiprogestogen is mifepristone.
Medical termination of pregnancy: mifepristone (partial agonist) combine with prostaglandin (e.g., gemeprost).
- ^ Spitz, IM. (Oct 2006). "Progesterone receptor antagonists.". Curr Opin Investig Drugs 7 (10): 882–90. PMID 17086932.
- ^ Tang, OS.; Ho, PC. (Dec 2006). "Clinical applications of mifepristone.". Gynecol Endocrinol 22 (12): 655–9. doi:10.1080/09513590601005946. PMID 17162706.
- Antiprogestin entry in the public domain NCI Dictionary of Cancer Terms
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".