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An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants, and bacteria. Although they are most effective in neutralizing toxins, they can kill bacteria and other microorganisms. Antitoxins are made within organisms, but can be injected into other organisms, including humans. This procedure involves injecting an animal with a safe amount of a particular toxin. Then, the animal’s body makes the antitoxin needed to neutralize the toxin. Later, the blood is withdrawn from the animal. When the antitoxin is obtained from the blood, it is purified and injected into a human or other animal, inducing passive immunity. To prevent serum sickness, it is often best to use antitoxin generated from the same species (e.g. use human antitoxin to treat humans).
Antitoxins to diphtheria and tetanus toxins were produced by Emil Adolf von Behring and his colleagues from 1890 onwards. The use of diphtheria antitoxin for the treatment of diphtheria was regarded by the Lancet as the "most important advance of the [19th] Century in the medical treatment of acute infectious disease".
- (Report) (1896). "Report of the Lancet special commission on the relative strengths of diphtheria antitoxic antiserums". Lancet 148 (3803): 182–95.
- Dolman, C.E. (1973). "Landmarks and pioneers in the control of diphtheria". Can. J. Publ. Health 64: 317–36.
- Antitoxins at the US National Library of Medicine Medical Subject Headings (MeSH)
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