A gravel road called Antone Lane runs south of and roughly parallel to Route 26, to which it connects both east of Mitchell, in Wheeler County, and west of Dayville, in Grant County. The road crosses Rock Creek, a tributary of the John Day River, at Antone. The Ochoco Mountains and the Ochoco National Forest are directly south of Antone.
The location was named in the early 1890s for Antone Francisco, a pioneer settler of Portuguese descent. A post office operated in Antone from 1894 through 1948 except for a three-year hiatus.