Born in Valencia, Guijarro grew up in poverty, but despite this was able to study in the Andresiano School of his native city, and attended the University of Valencia and later the University of Madrid earning his degree, where he majored in law and become a consultant in the court. He was very much a traditionalist and believer in retaining Catholic religious values and ideals, and did much for as a journalist and writer. In 1843, he founded the magazine La Restauración, and in 1855 the newspaper El Pensamiento of Valencia. In 1858 he was appointed deputy to Congress representing Valencia. From 1862 to 1872 he directed La Regeneración, and in these years also collaborated in La Esperanza and La Estrella. In 1865 he was again deputy for Valencia and Pamplona and the following year was named a member of the Real Academia de la Lengua. On the revolution of September 1868 he was forced into exile in France. In 1870 he attended a conference on carlism in VeveySwitzerland and in that same year received a private audience with Pope Pius IX. On his return to Spain he was elected senator of Guipúzcoa province, a position he held until his death on 8 November 1872.
Very influenced in his thought by Jaime Balmes and Donoso Cortés, his work today is an important example of Spanish traditionalism.