Floro Flores was born in Naples, and started his career at Napoli. He made his Serie A debut on 28 January 2001 against Roma. After six months on loan to Serie A Sampdoria, Floro Flores transferred to Perugia after the club had gone bankrupt. At Perugia, Floro Flores scored 8 goals in Serie B, and two more against Treviso in the promotion play-off second legs. But Perugia also faced bankruptcy, and Floro Flores joined Arezzo in the summer of 2005. He remained at the club for two seasons and scored 28 goals in 79 league matches. After Arezzo got relegated to Serie C1 on summer 2007, he was signed by Udinese Calcio in co-ownership deal. In 2011 he was loaned to Genoa and was in fine form for his new club scoring 10 goals in 18 matches. In August 2011 he signed a new 5-year contract with Udinese. During the summer of 2012 he was sent on loan to Granada in La Liga. On 16 September 2012 Antonio Floro Flores scored his first goal for Granada in the 82nd minute against Deportivo to lead his side to a come from behind draw.