||This article's lead section may not adequately summarize key points of its contents. (March 2013)|
Schematic view of the aorta and a number of its most important branches
|Latin||Aorta, arteria maxima|
|Supplies||The systemic circulation
(entire body with exception of the respiratory zone of the lung which is supplied by the pulmonary circulation)
Arch of aorta (supra-aortic vessels):
Descending aorta, thoracic part:
Descending aorta, abdominal part:
|Vein||Combination of coronary sinus, superior vena cava and inferior vena cava|
|Precursor||Paired dorsal aortae (combine into the single descending aorta)|
The aorta (//) is the largest artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it bifurcates into two smaller arteries (the common iliac arteries). The aorta distributes oxygenated blood to all parts of the body through the systemic circulation.
In anatomical sources, the aorta is usually divided into sections.
  One way of classifying a part of the aorta is by anatomical compartment, where the thoracic aorta (or thoracic part of the aorta) runs from the heart to the thoracic diaphragm. The aorta then continues as the abdominal aorta (or abdominal part of the aorta) diaphragm to the aortic bifurcation. Another system divides the aorta with respect to its course and the direction of blood flow. In this system, the aorta starts as the ascending aorta (or ascending part of the aorta), taking a superior course from the heart, but then making a hairpin turn, the aortic arch or arch of aorta. The part after this hairpin turn takes an inferior course and is known as the descending aorta. The descending aorta has two parts. The aorta begins to descend in the thoraic cavity, and consequently is known as the thoracic aorta. After the aorta passes through the diaphragm, it is known as the abdominal aorta. The aorta ends by dividing into two major blood vessels, the common iliac arteries and a smaller midline vessel, the median sacral artery. :18
The ascending aorta originates at the orifice of the aortic valve. It runs in a common pericardial sheath with the pulmonary trunk. These two blood vessels twist around each other, so that the aorta starts out posterior to the pulmonary trunk, but then twists to its right and anterior side.  :191, 204 The transition from ascending aorta to aortic arch is at the pericardial reflection on the aorta. :Plate 211
At the root of the ascending aorta, the lumen has three little pockets between the cusps of the aortic valve and the wall of the aorta, named the aortic sinuses or sinuses of Valsalva. The left aortic sinus contains the origin of the left coronary artery and the right aortic sinus likewise gives rise to the right coronary artery. Together, these two arteries normally supply the heart. The posterior aortic sinus does not give rise to a coronary artery. For this reason, the left, right and posterior aortic sinuses are also called left-coronary, right-coronary and non-coronary sinuses.:191
The aortic arch loops over the right pulmonary artery and the bifurcation of the pulmonary trunk, with which it remains connected by the ligamentum arteriosum, a remnant of the fetal circulation that is obliterated a few days after birth. In addition to these blood vessels, the aortic arch crosses the left main bronchus. Between it and the pulmonary trunk is a network of autonomic nerve fibers, the cardiac or aortic plexus. The left vagus nerve, which passes anterior to the aortic arch, gives off a major branch, the recurrent laryngeal nerve, which loops under the aortic arch just lateral to the ligamentum arteriosum. It then runs back to the neck.
The aortic arch has three major branches: from proximal to distal they are the brachiocephalic trunk, which supplies the right side of the head and neck, as well as the right arm and chest wall, the left common carotid artery, and the left subclavian artery. The latter two together supply the left side of the same regions.
The thoracic descending aorta gives rise to the intercostal and subcostal arteries, as well as to the superior and inferior left bronchial arteries and variable branches to the oesophagus, mediastinum, and pericardium. Its lowest pair of branches are the superior phrenic arteries, which supply the diaphragm, and the subcostal arteries for the twelfth rib. :195
The abdominal aorta gives rise to lumbar and musculophrenic arteries, renal and middle suprarenal arteries, and visceral arteries (the celiac trunk, the superior mesenteric artery and the inferior mesenteric artery). It ends in a bifurcation into the left and right common iliac arteries. At the point of the bifurcation, there also springs a smaller branch, the median sacral artery. :331
In mammalian and avian embryological development, the pharyngeal arch (aortic arches) arteries contribute to the normal pattern of the great arteries. The fourth aortic arch vessel survives in these vertebrates as the arch of the aorta, the third aortic arch vessel persists as the brachiocephalic artery or the root of the internal carotid, and the sixth arch contributes to the pulmonary arteries. The smooth muscle of the great arteries and the population of cells that form the aorticopulmonary septum that separates the aorta and pulmonary artery is derived from cardiac neural crest. This contribution of the neural crest to the great artery smooth muscle is unusual as most smooth muscle is derived from mesoderm. In fact the smooth muscle within the abdominal aorta is derived from mesoderm, and the coronary arteries, which arise just above the semilunar valves, possess smooth muscle of mesodermal origin. A failure of the aorticopulmonary septum to divide the great vessels results in persistent truncus arteriosus.
The aorta is an elastic artery, and as such is quite distensible. Mean arterial blood pressure is highest in the aorta and mean arterial pressure diminishes across the circulation from aorta to arteries to arterioles to capillaries to veins back to atrium: the difference between aortic and right atrial pressure accounts for blood flow in the circulation. The aorta consists of a heterogeneous mixture of smooth muscle, nerves, intimal cells, endothelial cells, fibroblast-like cells, and a complex extracellular matrix. The vascular wall consists of several layers known as the tunica adventitia, tunica media, and tunica intima. The thickness of the aorta encourages an extensive network of tiny blood vessels called vasa vasorum, which feed the outer layers of the aorta. The aortic arch contains baroreceptors and chemoreceptors that relay information concerning blood pressure and blood pH and carbon dioxide levels to the medulla oblongata of the brain. This information is processed by the brain and the autonomic nervous system mediates the homeostatic responses.
Within the tunica media, smooth muscle and the extracellular matrix are quantitatively the largest components of the aortic vascular wall. The fundamental unit of the aorta is the elastic lamella, which consists of smooth muscle and elastic matrix. The medial layer of the aorta consist of concentric musculoelastic layers (the elastic lamella) in mammals. The smooth muscle component does not dramatically alter the diameter of the aorta but rather serves to increase the stiffness and viscoelasticity of the aortic wall when activated. The elastic matrix dominates the biomechanical properties of the aorta. The elastic matrix forms lamella, consisting of elastic fibers, collagens(predominately type III), proteoglycans, and glycoaminoglycans. When the left ventricle contracts to force blood into the aorta, the aorta expands. This stretching gives the potential energy that will help maintain blood pressure during diastole, as during this time the aorta contracts passively. This Windkessel effect of the great elastic arteries has important biomechanical implications. The elastic recoil helps conserve the energy from the pumping heart and smooth out the pulsatile nature created by the heart. Aortic pressure is highest at the aorta and becomes less pulsatile and lower pressure as blood vessels divide into arteries, arterioles, and capillaries such that flow is slow and smooth for gases and nutrient exchange.
Variations may occur in the location of the aorta, and the way in which arteries branch off the aorta. The aorta, normally on the left side of the body, may be found on the right in dextrocardia, in which the heart is found on the right, or situs inversus, in which the location of all organs are flipped. :188
The aorta supplies all of the systemic circulation, which means that the entire body, except for the respiratory zone of the lung gets its blood from the aorta. Broadly speaking, branches from the ascending aorta supply the heart, branches from the aortic arch supply the head, neck and arms, branches from the thoracic descending aorta supply the chest (excluding the heart and the respiratory zone of the lung) and branches from the abdominal aorta supply the abdomen. The pelvis and legs get their blood from the common iliac arteries.
Blood flow and velocity
The pulsatile nature of blood flow creates a pulse wave that is propagated down the arterial tree, and at bifurcations reflected waves rebound to return to semilunar valves and the origin of the aorta. These return waves create the dicrotic notch displayed in the aortic pressure curve during the cardiac cycle as these reflected waves push on the aortic semilunar valve. With age, the aorta stiffens such that the pulse wave is propagated faster and reflected waves return to the heart faster before the semilunar valve closes, which raises the blood pressure. The stiffness of the aorta is associated with a number of diseases and pathologies, and noninvasive measures of the pulse wave velocity are an independent indicator of hypertension. Measuring the pulse wave velocity (invasively and non-invasively) is a means of determining arterial stiffness. Maximum aortic velocity may be noted as Vmax or less commonly as AoVmax.
- Aortic aneurysm – myotic, bacterial (e.g. syphilis), senile, genetic, associated with valvular heart disease
- Aortic dissection
- Aortic coarctation – pre-ductal, post-ductal
- Transposition of the great vessels, see also dextro-Transposition of the great arteries and levo-Transposition of the great arteries
- Marfan syndrome
- Ehlers–Danlos syndrome
- Aortic stenosis
- Trauma, such as traumatic aortic rupture, most often thoracic and distal to the left subclavian artery and frequently quickly fatal
In other animals
All amniotes have a broadly similar arrangement to that of humans, albeit with a number of individual variations. In fish, however, there are two separate vessels referred to as aortas. The ventral aorta carries de-oxygenated blood from the heart to the gills; part of this vessel forms the ascending aorta in tetrapods (the remainder forms the pulmonary artery). A second, dorsal aorta carries oxygenated blood from the gills to the rest of the body, and is homologous with the descending aorta of tetrapods. The two aortas are connected by a number of vessels, one passing through each of the gills. Amphibians also retain the fifth connecting vessel, so that the aorta has two parallel arches.
The word 'Aorta' stems from the Late Latin Latin: aorta from aortē (Greek: ἀορτή), from aeirō, "I lift, raise" (Greek: ἀείρω) This term was first applied by Aristotle when describing the aorta. 
This article uses anatomical terminology; for an overview, see anatomical terminology.
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