Apetala 2

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AP2 domain
PDB 3gcc EBI.jpg
Structure of the GCC-box binding domain in complex with DNA.[1]
Identifiers
Symbol AP2
Pfam PF00847
Pfam clan CL0081
InterPro IPR001471
SMART SM00380
PROSITE PS51032
SCOP 3gcc
SUPERFAMILY 3gcc
Apetala 2
Identifiers
Symbol AP2
Entrez 829845
UniProt P47927
Not to be confused with AP2 adaptors. ‹See Tfd›

Apetala 2 (AP2) is a gene coding for a member of a large family of transcription factors, the AP2/EREBP family. In Arabidopsis thaliana which plays a role in the ABC model of flower development.[2] It was originally thought that this family of proteins was plant-specific, however recent studies have shown that apicomplexans, including the causative agent of malaria, Plasmodium falciparum encode a related set of transcription factors, called the ApiAP2 family.[3]

In the A. thaliana transcription factor RAV1 the N-terminal AP2 domain binds 5'-CAACA-3' sequence, while the C-terminal highly conserved B3 domain binds 5'-CACCTG-3' sequence.[4]

References[edit]

  1. ^ Allen MD, Yamasaki K, Ohme-Takagi M, Tateno M, Suzuki M (September 1998). "A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA". EMBO J. 17 (18): 5484–96. doi:10.1093/emboj/17.18.5484. PMC 1170874. PMID 9736626. 
  2. ^ Riechmann JL, Meyerowitz EM (1998). "The AP2/EREBP family of plant transcription factors". Biol. Chem. 379 (6): 633–46. doi:10.1515/bchm.1998.379.6.633. PMID 9687012. 
  3. ^ Balaji S, Babu MM, Iyer LM, Aravind L (2005). "Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains". Nucleic Acids Research 33 (13): 3994–4006. doi:10.1093/nar/gki709. PMC 1178005. PMID 16040597. 
  4. ^ Kagaya Y, Ohmiya K, Hattori T (1999). "RAV1, a novel DNA-binding protein, binds to bipartite recognition sequence through two distinct DNA-binding domains uniquely found in higher plants". Nucleic Acids Res. 27 (2): 470–8. doi:10.1093/nar/27.2.470. PMC 148202. PMID 9862967. 

External links[edit]