Apicomplexan life cycle

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Cellular structure of a typical, generalised Apicomplexan: 1-polar ring, 2-conoid, 3-micronemes, 4-rhoptries, 5-nucleus, 6-nucleolus, 7-mitochondria, 8-posterior ring, 9-alveoli, 10-golgi apparatus, 11-micropore.

Apicomplexans, a group of intracellular parasites, have life cycle stages evolved to allow them to survive the wide variety of environments they are exposed to during their complex life cycle.[1] Each stage in the life cycle of an apicomplexan organism is typified by a cellular variety with a distinct morphology and biochemistry.

Not all apicomplexa develop all the following cellular varieties and division methods. This presentation is intended as an outline of a hypothetical generalised apicomplexan organism.

Methods of asexual replication[edit]

Apicomplexans (sporozoans) replicate via ways of multiple fission (also known as schizogony). These ways include gametogony, sporogony and merogony, although the latter is sometimes referred to as schizogony, despite its general meaning.[2]

Merogony is an asexually reproductive process of apicomplexa. After infecting a host cell, a trophozoite (see glossary below) increases in size while repeatedly replicating its nucleus and other organelles.[3] During this process, the organism is known as a meront or schizont. Cytokinesis next subdivides the multinucleated schizont into numerous identical daughter cells called merozoites (see glossary below), which are released into the blood when the host cell ruptures. Organisms whose life cycles rely on this process include Theileria, Babesia,[4] as well as the malaria parasite Plasmodium.[5]

Sporogony is a type of sexual and asexual reproduction. It involves karyogamy, the formation of a zygote which is followed by meiosis and multiple fission. This results in the production of sporozoites.

Other forms of replication include endodyogeny and endopolygeny.

Endodyogeny is a process of asexual reproduction, favoured by parasites such as Toxoplasma gondii. It involves an unusual process in which two daughter cells are produced inside a mother cell, which is then consumed by the offspring prior to their separation.[6]

Endopolygeny is the division into several organisms at once by internal budding.[6]

Glossary of cell types[edit]

An ookinete (motile), a sporozoite (motile) and a merozoite (non-motile) of Plasmodium falciparum.

Infectious stages[edit]

A sporozoite (G. sporos, seed + zōon, animal) is the cell form that infects new hosts. In Plasmodium, for instance, the sporozoites are cells that develop in the mosquito's salivary glands, leave the mosquito during a blood meal, and enter liver cells (hepatocytes) where they multiply. Cells infected with sporozoites eventually burst, releasing merozoites into the bloodstream.[8] Sporozoites are motile and they move by gliding.

A merozoite (G. meros, part [of a series], +zōon, animal) is the result of merogony that takes place within a host cell. In coccidiosis, merozoites form the first phase of the internal life cycle of coccidian. In the case of Plasmodium, merozoites infect red blood cells and then rapidly reproduce asexually. The red blood cell host is destroyed by this process, which releases many new merozoites that go on to find new blood-borne hosts. Merozoites are non-motile.

A gametocyte (G. gametēs, partner + kytos, cell) is a name given to a parasite's gamete-forming cells. A male gametocyte divides to give many flagellated microgametes, whereas the female gametocyte differentiates to a macrogamete.[9]

An ookinete (G. ōon, egg + kinētos, motile) is a fertilised zygote capable of moving spontaneously. It penetrates epithelial cells lining the midgut of mosquitoes to form a thick-walled structure known as an oocyst under the mosquito's outer gut lining.[10] Ookinetes are motile and they move by gliding.

A trophozoite (G. trophē, nourishment + zōon, animal) is the activated, intracellular feeding stage in the apicomplexan life cycle. After gorging itself on its host, the trophozoite undergoes schizogony and develops into a schizont, later releasing merozoites.

A bradyzoite (G. bradys, slow + zōon, animal) is a sessile, slow-growing form of zoonotic microorganisms such as Toxoplasma gondii, among others responsible for parasitic infections. In chronic (latent) toxoplasmosis, bradyzoites microscopically present as clusters enclosed by an irregular crescent-shaped wall (a pseudocyst) in infected muscle and brain tissues.

A tachyzoite (G. tachys, fast + zōon, animal), contrasting with a bradyzoite, is a form typified by rapid growth and replication. Tachyzoites are the motile forms of those coccidians which form tissue cysts, such as Toxoplasma and Sarcocystis. Typically infecting cellular vacuoles, tachyzoites divide by endodyogeny and endopolygeny.

An oocyst (G. ōon, egg + kystis, bladder) is a hardy, thick-walled spore, able to survive for lengthy periods outside a host. The zygote develops within the spore, which acts to protect it during transfer to new hosts. Organisms that create oocysts include Plasmodium, Cryptosporidium, and Toxoplasma.

See also[edit]

References[edit]

  1. ^ Jadwiga Grabda (1991). Marine fish parasitology: an outline. VCH. p. 8. ISBN 0-89573-823-6. 
  2. ^ Yoshinori Tanada, Harry K. Kaya (1993). Insect pathology. Gulf Professional Publishing. ISBN 978-0-12-683255-6. 
  3. ^ "Schizogony definition". MSN Encarta. Retrieved 2009-12-11. 
  4. ^ Herwaldt et al.; Persing, DH; Précigout, EA; Goff, WL; Mathiesen, DA; Taylor, PW; Eberhard, ML; Gorenflot, AF (1 April 1996). "A Fatal Case of Babesiosis in Missouri: Identification of Another Piroplasm That Infects Humans". Annals of Internal Medicine 124 (7): 643–650. doi:10.1059/0003-4819-124-7-199604010-00004. PMID 8607592. Retrieved 2009-12-11. 
  5. ^ Zhou et al.; Liu, Q.; Wongsrichanalai, C.; Suwonkerd, W.; Panart, K.; Prajakwong, S.; Pensiri, A.; Kimura, M. et al. (6 January 2002). "High prevalence of Plasmodium malariae and Plasmodium ovale in malaria patients along the Thai-Myanmar border, as revealed by acridine orange staining and PCR-based diagnoses". Tropical Medicine & International Health 3 (4): 304–312. doi:10.1046/j.1365-3156.1998.00223.x. Retrieved 2009-12-11. 
  6. ^ a b James Desmond Smyth, Derek Wakelin (1994). Introduction to animal parasitology (3 ed.). Cambridge University Press. pp. 101–102. ISBN 0-521-42811-4. 
  7. ^ Rigoulet, Jacques; Hennache, Alain; Lagourette, Pierre; George, Catherine; Longeart, Loïc; Le Net, Jean-Loïc; Dubey, Jitender P. (2014). "Toxoplasmosis in a bar-shouldered dove (Geopelia humeralis) from the Zoo of Clères, France". Parasite 21: 62. doi:10.1051/parasite/2014062. ISSN 1776-1042. PMID 25407506.  open access publication - free to read
  8. ^ "Malaria - Life Cycle Of Plasmodium.swf". esnips. Archived from the original on 21 November 2009. Retrieved 2009-12-11. 
  9. ^ Sinden, R. E.; Talman, A.; Marques, S. R.; Wass, M. N.; Sternberg, M. J. E. (2010). "The flagellum in malarial parasites". Current Opinion in Microbiology 13 (4): 491–500. doi:10.1016/j.mib.2010.05.016. PMID 20566299.  edit
  10. ^ "Ookinete (Medical Dictionary)". Dictionary.com. Retrieved 2009-12-11.