|CAS number||clarification needed][|
|Molar mass||222.23 g/mol|
|Melting point||30 °C (86 °F; 303 K)|
|Boiling point||294 °C (561 °F; 567 K)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|what is: / ?)(|
Apiol is a phthalide, also known as parsley apiol, apiole or parsley camphor. It is found in the essential oils of celery leaf and all parts of parsley. Heinrich Christoph Link, an apothecary in Leipzig, discovered the substance in 1715 as greenish crystals reduced by steam from oil of parsley. In 1855 Joret and Homolle discovered that apiol was an effective treatment of amenorrea or lack of menstruation.
In medicine it has been used, as essential oil or in purified form, for the treatment of menstrual disorders and as an abortifacient. It is an irritant and, in high doses, it can cause liver and kidney damage. Cases of death due to attempted abortion using apiol have been reported.
Hippocrates wrote about parsley as a herb to cause an abortion. Plants containing apiol were used by women in the Middle Ages to terminate pregnancies. Its use was widespread in the USA, often as ergoapiol or apergol, until a highly toxic adulterated product containing apiol and tri-ortho-cresyl phosphate (also famous as the adulterant added to Jamaican ginger) was introduced on the American market. No carcinogenicity was detected with parsley apiol or dill apiol in mice.
Now that safer methods of abortion are available, apiol is almost forgotten.
- Azeez, Shamina; Krishnamurthy, K. (2008). Chemistry of Spices. Calicut, Kerala, India: Biddles Ltd. pp. 380 & 404. ISBN 9781845934057.
- Shorter, Edward (1991). Women's Bodies: A Social History of Women's Encounter With Health, Ill-Health, and Medicine. New Brunswick, NJ: Transaction Publishers.
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- Sage-Femme Collective (2008). Natural Liberty: Rediscovering Self-Induced Abortion Methods. Sage-Femme Collective. ISBN 978-0964592001.
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- Apiol chemical information from chemindustry.com
- Apiol in the ChemIDplus database
- Essential oil from fennel plants--studies on the composition