Apitoxin, or honey bee venom, is a bitter colourless liquid; its active portion a mixture of proteins, which causes local inflammation and acts as an anticoagulant. A honeybee can inject 0.1 mg of venom via its stinger. It may have similarities to sea nettle toxin.
Components of Apitoxin
- Apamin increases cortisol production in the adrenal gland. Apamin is a mild neurotoxin.
- Adolapin, contributing 2–5% of the peptides, acts as an anti-inflammatory and analgesic because it blocks cyclooxygenase.
- Phospholipase A2 amounts to 10–12% of peptides and it is the most destructive component of apitoxin. It is an enzyme which degrades the phospholipids which cellular membranes are made of. It also causes decreased blood pressure and inhibits blood coagulation. Phospholipase A2 activates arachidonic acid which is metabolized in the cyclooxygenase-cycle to form prostaglandins. Prostaglandins regulate the body's inflammatory response.
- Hyaluronidase contributing 1–3% of peptides dilates the capillaries causing the spread of inflammation.
- Histamine contributing 0.5–2% and is involved in the allergic response.
- Dopamine and noradrenaline which contribute 1–2% increase pulse rate.
- Protease-inhibitors contribute 2% and act as anti-inflammatory agents and stop bleeding.
Bee venom therapy
Bee venom therapy is used by some as a treatment for rheumatism and joint diseases due to its anticoagulant and anti-inflammatory properties. It is also used to desensitize people allergic to insect stings. Bee venom therapy can also be delivered in the form of a balm although this may be less potent than using live bee stings. Bee venom can be found in numerous beauty products. It is believed to increase blood flow therefore plumping the applied area, producing collagen. This effect aids in smoothing out lines and wrinkles.
- Czarnetzki, B. M.; Thiele, T.; Rosenbach, T. (February 1990). "Evidence for leukotrienes in animal venoms". The Journal of allergy and clinical immunology 85 (2): 505–509. doi:10.1016/0091-6749(90)90162-W. PMID 1968071.
- Meier J, White J. (1995). Clinical toxicology of animal venoms and poisons. CRC Press, Inc. ISBN 0-8493-4489-1.
- "Treatment with Bee Venom".
- "Top 5 Weird Ingredients Found In Beauty Products".