Apolipoprotein C1

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Apolipoprotein C-I

PDB rendering based on 1ioj.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol APOC1
External IDs OMIM107710 MGI88053 HomoloGene1244 GeneCards: APOC1 Gene
Orthologs
Species Human Mouse
Entrez 341 11812
Ensembl ENSG00000130208 ENSMUSG00000040564
UniProt P02654 P34928
RefSeq (mRNA) NM_001645 NM_001110009
RefSeq (protein) NP_001636 NP_001103479
Location (UCSC) Chr 19:
45.42 – 45.42 Mb
Chr 7:
19.69 – 19.69 Mb
PubMed search [1] [2]
ApoC-I
PDB 1eze EBI.jpg
structural studies of a baboon (papio sp.) plasma protein inhibitor of cholesteryl ester transferase.
Identifiers
Symbol ApoC-I
Pfam PF04691
InterPro IPR006781
SCOP 1ale
SUPERFAMILY 1ale

Apolipoprotein C-I is a protein component of lipoproteins that in humans is encoded by the APOC1 gene.[1][2]

Function[edit]

The protein encoded by this gene is a member of the apolipoprotein C family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within an apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.[3]

Apolipoprotein C1 has a length of 57 amino acids normally found in plasma and responsible for the activation of esterified lechitin cholesterol with an important role in the exchange of esterified cholesterol between lipoproteins and in removal of cholesterol from tissues. Its main function is inhibition of CETP, probably by altering the electric charge of HDL molecules.

During fasting (like other apolipoprotein C), it is found primarily within HDL, while after a meal it is found on the surface of other lipoproteins. When proteins rich in triglycerides like chylomicrons and VLDL are broken down, this apoprotein is transferred again to HDL. It is one of the most positively charged proteins in the human body.

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

References[edit]

  1. ^ Tata F, Henry I, Markham AF, Wallis SC, Weil D, Grzeschik KH, Junien C, Williamson R, Humphries SE (1985). "Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19". Hum. Genet. 69 (4): 345–9. doi:10.1007/BF00291654. PMID 2985493. 
  2. ^ Smit M, van der Kooij-Meijs E, Frants RR, Havekes L, Klasen EC (January 1988). "Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia". Hum. Genet. 78 (1): 90–3. doi:10.1007/BF00291243. PMID 2892779. 
  3. ^ "Entrez Gene: APOC1 apolipoprotein C-I". 

Further reading[edit]