Apolipoprotein C2

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Apolipoprotein C-II

PDB rendering based on 1by6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols APOC2 ; APO-CII; APOC-II
External IDs OMIM608083 MGI88054 HomoloGene47928 GeneCards: APOC2 Gene
Orthologs
Species Human Mouse
Entrez 344 11813
Ensembl ENSG00000224916 ENSMUSG00000002992
UniProt P02655 Q05020
RefSeq (mRNA) NM_000483 NM_001277944
RefSeq (protein) NP_000474 NP_001264873
Location (UCSC) Chr 19:
45.45 – 45.45 Mb
Chr 7:
19.67 – 19.68 Mb
PubMed search [1] [2]
Apo-CII
PDB 1i5j EBI.jpg
nmr structure of human apolipoprotein c-ii in the presence of sds
Identifiers
Symbol Apo-CII
Pfam PF05355
InterPro IPR008019
SCOP 1by6
SUPERFAMILY 1by6

Apolipoprotein C2 or Apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries,[1] which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

See also[edit]

References[edit]

  1. ^ Kim SY, Park SM, Lee ST (2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun. 339 (1): 47–54. doi:10.1016/j.bbrc.2005.10.182. PMID 16314153. 
  2. ^ "Entrez Gene: APOC2 apolipoprotein C-II".