Appendix cancer

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Appendix cancer
Classification and external resources
ICD-10 C18.1, C78.5
ICD-9 153.5
NCI Appendix cancer
MeSH D001063

Appendix cancer or appendiceal cancer are rare malignancies of the vermiform appendix.

Gastrointestinal stromal tumors are rare tumors with malignant potential. Primary lymphomas can occur in the appendix. Breast cancer, colon cancer, and tumors of the female genital tract may metastasize to the appendix.[1]


The treatment for tumors varies. Small carcinoids (<2 cm) without features of malignancy may be treated by appendectomy if complete removal is possible. Other carcinoids and adenocarcinomas may require right hemicolectomy.

Pseudomyxoma peritonei treatment includes cytoreductive surgery which includes the removal of visible tumor and affected essential organs within the abdomen and pelvis. The peritoneal cavity is infused with heated chemotherapy known as HIPEC in an attempt to eradicate residual disease. The surgery may or may not be preceded or followed with intravenous chemotherapy or HIPEC.[2]


A study of primary malignacies in the United States found a rate of 0.12 cases per 1,000,000 population per year. Carcinoids that were not identified as malignant were not included in this data.[3] Carcinoid is found in roughly 1 in 300 appendectomies for acute appendicitis.[citation needed] A Hong Kong case series of 1492 appendectomies identified 17 neoplasms. Eight were carcinoids without specification of malignant features. Three cases of adenocarcinoma, and one each of cystadenocarcinoma, psedomyxoma peritoneii, and metastasic carcinoma were identified. The remaining tumors were benign.[4] It was previously believed that carcinoid tumors are the most common tumors of the appendix but now data from SEER ( Surveillane, epidimology and End results) show that mucinous adenocarcinomas are more common[5]

Notable cases[edit]

Actress Audrey Hepburn was diagnosed with appendix cancer, and died of the disease in 1993.[6] ESPN anchor Stuart Scott is also battling appendix cancer.[7]


  1. ^ Rosai, Juan (2004) [1953]. "11. Gastrointestinal tract". Rosai and Ackerman's surgical pathology (9th ed.). Mosby. pp. 761–769. 
  2. ^ M. Townsend, Courtney (2012) [1969]. "51. The appendix". Sabiston (18th ed.). Elsevier. p. 1289. 
  3. ^ McCusker, M. E.; Coté, T. R.; Clegg, L. X.; Sobin, L. H. (2002). "Primary malignant neoplasms of the appendix". Cancer 94 (12): 3307–3312. doi:10.1002/cncr.10589. PMID 12115365.  edit
  4. ^ Ma, KW; Chia, NH; Yeung, HW; Cheung, MT (2010). "If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies". Hong Kong medical 16 (1): 12–7. PMID 20124568.  edit
  5. ^ Sabiston Principles of Surgery (18th ed.). p. 1344. 
  6. ^ Selim, Jocelyn (Fall 2009), "The Fairest of All", CR (Philadelphia: American Association for Cancer Research) 4 (4), retrieved January 22, 2011 
  7. ^

Further reading[edit]

External links[edit]