Aprindine

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Aprindine
Aprindine.svg
Systematic (IUPAC) name
{3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 37640-71-4
ATC code C01BB04
PubChem CID 2218
DrugBank DB01429
ChemSpider 2132 YesY
UNII 5Y48085P9Q YesY
KEGG D02969 YesY
ChEMBL CHEMBL1213033 YesY
Chemical data
Formula C22H30N2 
Mol. mass 322.487 g/mol
 YesY (what is this?)  (verify)

Aprindine is a Class 1b antiarrhythmic agent.[1]

In one study, it delayed atrial fibrillation more than digoxin did.[2]

It has shown effectiveness when given orally.[3]

References[edit]

  1. ^ Sato R, Hisatome I, Tanaka Y, et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104. 
  2. ^ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation" ([dead link]). Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271. 
  3. ^ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.