Aquaporin 4

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aquaporin 4
PDB 2d57 EBI.png
Double layered 2D crystal structure of aquaporin-4 (AQP4M23) at 3.2 a resolution by electron crystallography.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AQP4 ; HMIWC2; MIWC
External IDs OMIM600308 MGI107387 HomoloGene37507 IUPHAR: AQP4 ChEMBL: 5964 GeneCards: AQP4 Gene
Orthologs
Species Human Mouse
Entrez 361 11829
Ensembl ENSG00000171885 ENSMUSG00000024411
UniProt P55087 P55088
RefSeq (mRNA) NM_001650 NM_009700
RefSeq (protein) NP_001641 NP_033830
Location (UCSC) Chr 18:
24.43 – 24.45 Mb
Chr 18:
15.39 – 15.4 Mb
PubMed search [1] [2]

Aquaporin 4 also known as AQP4 is a protein which in humans is encoded by the AQP4 gene.[1] AQP4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane.

Function[edit]

AQP4 is constitutively expressed in the basolateral cell membrane of principal collecting duct cells in the kidney and provide a pathway for water to exit these cells.[2]

AQP4 is also expressed in astrocytes and is upregulated by direct insult to the central nervous system.[3]

Pathology[edit]

Aquaporin-4 has been proposed as the primary autoimmune target in neuromyelitis optica.[4][5]

See also[edit]

References[edit]

  1. ^ Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P (December 1994). "Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance". Proceedings of the National Academy of Sciences of the United States of America 91 (26): 13052–6. doi:10.1073/pnas.91.26.13052. PMC 45579. PMID 7528931. 
  2. ^ Agre P, Nielsen S (1996). "The aquaporin family of water channels in kidney". Nephrologie 17 (7): 409–15. PMID 8987045. 
  3. ^ Nagelhus EA, Mathiisen TM, Ottersen OP (2004). "Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1". Neuroscience 129 (4): 905–13. doi:10.1016/j.neuroscience.2004.08.053. PMID 15561407. 
  4. ^ Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (August 2005). "IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel". J. Exp. Med. 202 (4): 473–7. doi:10.1084/jem.20050304. PMC 2212860. PMID 16087714. 
  5. ^ Bradl M, Lassmann DH (September 2008). "Anti-aquaporin-4 antibodies in neuromyelitis optica: how to prove their pathogenetic relevance?". International MS Journal / MS Forum 15 (3): 75–8. PMID 18812056. 


Further reading[edit]

External links[edit]