An aquaretic is a class of drug that is used to promote aquaresis, the excretion of water without electrolyte loss. Aquaretics are not strictly speaking diuretics, but are sometimes classified as such.
Aquaretics increase blood flow to the kidneys without increasing sodium and chloride resorption, thus causing an increase in urine whilst retaining electrolytes. However, the increase in intravascular fluid volume that they cause translates into an increase vascular resistance, and higher blood pressure.[dubious ]
Synthetic aquaretics are vasopressin receptor antagonists, such conivaptan, tolvaptan, demeclocycline and OPC-31260, as well as lithium. These have been used in clinical trials as a treatment for syndrome of inappropriate antidiuretic hormone (SIADH).
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- Toshikazu Saito, San-e Ishikawa, Keishi Abe, Kyuzi Kamoi, Kenichi Yamada, Kurakazu Shimizu, Takao Saruta and Sho Yoshida (April 1997). "Acute Aquaresis by the Nonpeptide Arginine Vasopressin (AVP) Antagonist OPC-31260 Improves Hyponatremia in Patients with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)". The Journal of Clinical Endocrinology & Metabolism (The Endocrine Society) 82 (4): 1054–1057. PMID 9100572.
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