Arachidonyl-2'-chloroethylamide

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Arachidonyl-2'-chloroethylamide
Arachidonyl-2-chloroethylamide.svg
Names
IUPAC name
N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Other names
Arachidonyl-2'-chloroethylamide; ACEA
Identifiers
220556-69-4 N
ChEMBL ChEMBL151167 YesY
ChemSpider 4470547 YesY
Jmol-3D images Image
PubChem 5311006
Properties
C22H36ClNO
Molar mass 365.98 g·mol−1
Solubility in other solvents soluble in ethanol, chloroform, THF and DMSO
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N
Infobox references

Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki = 1.4 nM for CB1R; Ki = 3100 nM for CB2R). [1]

References[edit]

  1. ^ Hillard, CJ; Manna, S; Greenberg, MJ; Dicamelli, R; Ross, RA; Stevenson, LA; Murphy, V; Pertwee, RG; Campbell, WB (1999). "Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)". The Journal of Pharmacology and Experimental Therapeutics 289 (3): 1427–33. PMID 10336536.