Archaeosine synthase

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Archaeosine synthase
Identifiers
EC number 2.6.1.97
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Archaeosine synthase (EC 2.6.1.97, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an enzyme with system name L-glutamine:7-cyano-7-carbaguanine aminotransferase.[1][2] This enzyme catalyses the following chemical reaction

L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O \rightleftharpoons L-glutamate + archaeine15 in tRNA

In Euryarchaeota the reaction is catalysed by ArcS.

References[edit]

  1. ^ Phillips, G., Chikwana, V.M., Maxwell, A., El-Yacoubi, B., Swairjo, M.A., Iwata-Reuyl, D. and de Crecy-Lagard, V. (2010). "Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA". J. Biol. Chem. 285: 12706–12713. doi:10.1074/jbc.M110.102236. PMC 2857094. PMID 20129918. 
  2. ^ Phillips, G., Swairjo, M.A., Gaston, K.W., Bailly, M., Limbach, P.A., Iwata-Reuyl, D. and de Crecy-Lagard, V. (2012). "Diversity of archaeosine synthesis in crenarchaeota". ACS Chem. Biol. 7 (2): 300–305. doi:10.1021/cb200361w. PMID 22032275. 

External links[edit]