Arenobufagin

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Arenobufagin
Arenobufagin.png
Identifiers
CAS number 464-74-4 YesY
PubChem 10051
ChemSpider 20051196 YesY
Jmol-3D images Image 1
Properties
Molecular formula C24H32O6
Molar mass 416.51 g mol−1
Hazards
Main hazards Toxic
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Arenobufagin is a cardiotoxic bufanolide steroid secreted by the Argentine toad Bufo arenarum.[1] It has effects similar to digitalis, blocking the Na+/K+ pump in heart tissue.[2]

References[edit]

  1. ^ Garraffo HM, Gros EG. Biosynthesis of bufadienolides in toads. VI. Experiments with [1,2-3H]cholesterol, [21-14C]coprostanol, and 5 beta-[21-14 C]pregnanolone in the toad Bufo arenarum. Steroids. 1986 Sep-Oct;48(3-4):251-7. PMID 3127947
  2. ^ Cruz J dos S, Matsuda H. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. European Journal of Pharmacology. 1993 Aug 3;239(1-3):223-6. PMID 8223897