Arfendazam

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Arfendazam
Arfendazam.svg
Systematic (IUPAC) name
Ethyl 7-chloro-4-oxo-5-phenyl-2,3-dihydro-1,5-benzodiazepine-1-carboxylate
Clinical data
Legal status ?
Identifiers
CAS number 37669-57-1
ATC code None
PubChem CID 65803
ChemSpider 59219 YesY
UNII P37G7BTX8V YesY
ChEMBL CHEMBL2104444
Chemical data
Formula C18H17ClN2O3 
Mol. mass 344.792
 YesY (what is this?)  (verify)

Arfendazam is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.

Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABAA receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses.[1][2]

Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects.[3]

See also[edit]

References[edit]

  1. ^ Müller E. Benzodiazepine receptor interactions of arfendazam, a novel 1, 5-benzodiazepine. Pharmacopsychiatry 1985, (18):10-11.
  2. ^ Müller WE, Groh B, Bub O. In vitro and in vivo studies of the mechanism of action of arfendazam, a novel 1, 5-benzodiazepine. Pharmacopsychiatry 1986, (10):314-315.
  3. ^ J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. The Pharmacology of Sleep. Springer. ISBN 978-3-540-58961-7