Arginine vasopressin receptor 2

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Arginine vasopressin receptor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols AVPR2 ; ADHR; DI1; DIR; DIR3; NDI; V2R
External IDs OMIM300538 MGI88123 HomoloGene20064 IUPHAR: V2 ChEMBL: 1790 GeneCards: AVPR2 Gene
Orthologs
Species Human Mouse
Entrez 554 12000
Ensembl ENSG00000126895 ENSMUSG00000031390
UniProt P30518 O88721
RefSeq (mRNA) NM_000054 NM_001276298
RefSeq (protein) NP_000045 NP_001263227
Location (UCSC) Chr HG1497_PATCH:
153.11 – 153.11 Mb
Chr X:
73.89 – 73.9 Mb
PubMed search [1] [2]

Arginine vasopressin receptor 2 (officially abbreviated AVPR2) is a protein that acts as receptor for arginine vasopressin.[1] AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the Gs type of G proteins, which stimulate adenylate cyclase.

AVPR2 is expressed in the kidney tubule, predominantly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed outside the kidney, and, when stimulated, a variety of clotting factors are released into the bloodstream.

In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of AVPR2 is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results.

Antagonists[edit]

Further information: Vasopressin receptor antagonist

Vasopressin receptor antagonists that are selective for the V2 receptor include:

Their main uses are in hyponatremia, such as that caused by syndrome of inappropriate antidiuretic hormone (SIADH) and heart failure, however these agents should be avoided in patients with cirrhosis.[2]

Interactions[edit]

Arginine vasopressin receptor 2 has been shown to interact with C1QTNF1.[3]

References[edit]

  1. ^ van den Ouweland AM, Knoop MT, Knoers VV, Markslag PW, Rocchi M, Warren ST, Ropers HH, Fahrenholz F, Monnens LA, van Oost BA (1992). "Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region". Genomics 13 (4): 1350–2. doi:10.1016/0888-7543(92)90067-3. PMID 1324225. 
  2. ^ http://www.samsca.com/documents/pdf/prescribing-information-samsca.pdf
  3. ^ Innamorati, Giulio; Whang Michael Insuk; Molteni Raffaella; Le Gouill Christian; Birnbaumer Mariel (Nov 2002). "GIP, a G-protein-coupled receptor interacting protein". Regul. Pept. (Netherlands) 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. ISSN 0167-0115. PMID 12409230. 

Further reading[edit]

External links[edit]