Arginylglycylaspartic acid

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Arginylglycylaspartic acid
Stereo, skeletal formula of arginylglycylaspartic acid
Identifiers
Abbreviations RGD Peptide
CAS number 99896-85-2 YesY
PubChem 3328704, 104802
ChemSpider 2575945 N, 94603 YesY
MeSH arginyl-glycyl-aspartic+acid
ChEMBL CHEMBL313763 N
Jmol-3D images Image 1
Properties
Molecular formula C12H22N6O6
Molar mass 346.34 g mol−1
log P −3.016
Acidity (pKa) 2.851
Basicity (pKb) 11.146
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Arginylglycylaspartic acid (RGD) is a tripeptide composed of L-arginine, glycine, and L-aspartic acid. The sequence is a common element in cellular recognition.[1] Arginylglycylaspartic acid is used as a biochemical tool in the study of this recognition.

RGD-peptides are implicated in cellular attachment via integrins, and can be used to coat synthetic scaffolds in tissue engineering to enhance cellular attachment by micking in vivo conditions.[2]

References[edit]

  1. ^ Ruoslahti, Erkki; Pierschbacher, Michael D. (1986). "Arg-Gly-Asp: a versatile cell recognition signal". Cell 44 (4): 517–18. doi:10.1016/0092-8674(86)90259-X. PMID 2418980. 
  2. ^ Jeschke, B; Meyer, J; Jonczyk, A; Kessler, H; Adamietz, P; Meenen, NM; Kantlehner, M; Goepfert, C; Nies, B (2002). "RGD-peptides for tissue engineering of articular cartilage". Biomaterials 23 (16): 3455–63. doi:10.1016/s0142-9612(02)00052-2. PMID 12099289.