Arias-Stella reaction

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Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue.[1]

Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer.[1]


It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.


It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions.[1]

Five subtypes are recognized:[1]

  1. Minimal atypia.
  2. Early secretory pattern.
  3. Secretory or hypersecretory pattern.
  4. Regenerative, proliferative or nonsecretory pattern.
  5. Monstrous cell pattern.


It was first described by Javier Arias Stella, a Peruvian pathologist in 1954.[2]

See also[edit]


  1. ^ a b c d Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after.". Adv Anat Pathol 9 (1): 12–23. doi:10.1097/00125480-200201000-00003. PMID 11756756. 
  2. ^ Arias-Stella, J. (Aug 1954). "Atypical endometrial changes associated with the presence of chorionic tissue.". Arch Pathol 58 (2): 112–28. PMID 13170908.