Warshel near Geneva, Switzerland, May 2009
November 20, 1940 |
Kibbutz Sde Nahum, Mandatory Palestine
|Fields||Chemistry, Biochemistry, Biophysics|
|Institutions||Weizmann Institute of Science
University of Southern California
Weizmann Institute of Science
|Known for||Computer simulation, Computational enzymology, electrostatics, enzyme catalysis|
|Notable awards||Nobel Prize in Chemistry (2013)|
Arieh Warshel (Hebrew: אריה ורשל, born November 20, 1940) is an Israeli and American biochemist and biophysicist. He is a Distinguished Professor of Chemistry and Biochemistry at the University of Southern California. He received the 2013 Nobel Prize in Chemistry, together with Michael Levitt and Martin Karplus for "the development of multiscale models for complex chemical systems".
Born in 1940 in kibbutz Sde Nahum, Mandatory Palestine (now in Israel). Served in the Israeli Armored Corps. After serving the Israeli Army (final rank Captain), Warshel attended the Technion, Haifa, where he received his BSc degree in Chemistry, Summa Cum Laude, in 1966. Subsequently, he earned both MSc and PhD degrees in Chemical Physics (in 1967 and 1969, respectively), with Shneior Lifson, Weizmann Institute of Science, Israel. After his PhD, he did postdoctoral work at Harvard University until 1972, and from 1972 to 1976 he returned to the Weizmann Institute and worked for the Laboratory of Molecular Biology, Cambridge, England. In 1976 he joined the faculty of the Department of Chemistry at USC. He was awarded the 2013 Nobel Prize in Chemistry.
Warshel is known for his work on computational biochemistry and biophysics, in particular for pioneering computer simulations of the functions of biological systems, and for developing what is known today as Computational Enzymology. He is a member of many scientific organisations, most importantly:
- Elected member of the United States National Academy of Sciences (2009)
- Fellow of the Royal Society of Chemistry (2008)
- Fellow of the Biophysical Society (2000)
- Alfred P. Sloan fellow (1978)
- Annual Award of the International Society of Quantum Biology and Pharmacology (1993)
- Tolman Medal (2003)
- President’s award for computational biology from the ISQBP (2006)
- RSC Soft Matter and Biophysical Chemistry Award (2012)
- Nobel Prize in Chemistry (2013) together with Martin Karplus and Michael Levitt for "for the development of multiscale models for complex chemical systems".
Major research achievements
Arieh Warshel made major contributions in introducing computational methods for structure function correlation of biological molecules, pioneering and co-pioneering programs, methods and key concepts for detailed computational studies of functional properties of biological molecules using Cartesian-based force field programs, the combined Quantum Chemistry/Molecular mechanics (i.e., QM/MM) method for simulating enzymatic reactions, the first molecular dynamics simulation of a biological process, microscopic electrostatic models for proteins, free energy perturbation in proteins and other key advances. It was for the development of these methods that Warshel shared the 2013 Nobel Prize in Chemistry.
- "The Nobel Prize in Chemistry 2013" (Press release). Royal Swedish Academy of Sciences. October 9, 2013. Retrieved October 9, 2013.
- Chang, Kenneth (October 9, 2013). "3 Researchers Win Nobel Prize in Chemistry". New York Times. Retrieved October 9, 2013.
- 3 Jewish professors — two of them Israeli — share 2013 Nobel Prize in chemistry By Gavriel Fiske, October 9, 2013, Times of Israel
- "Soft Matter and Biophysical Chemistry Award 2012 Winner". Rsc.org. Retrieved October 9, 2013.
- "Arieh Warshel Elected to the National Academy of Sciences > News > USC Dornsife". Dornsife.usc.edu. Retrieved October 9, 2013.
- "Arieh Warshel Elected to Royal Society of Chemistry > News > USC Dornsife". Dornsife.usc.edu. Retrieved October 9, 2013.
- "Fellow of the Biophysical Society Award". Biophysics.org. Retrieved October 9, 2013.
- "Past Fellows". Sloan.org. July 18, 2012. Retrieved October 9, 2013.
- "ISQBP People". Isqbp.umaryland.edu. Retrieved October 9, 2013.
- "Tolman Award". Scalacs. September 5, 1948. Retrieved October 9, 2013.
- Lifson S, Warshel A. (1968). "A Consistent Force Field for Calculation on Conformations, Vibrational Spectra and Enthalpies of Cycloalkanes and n-Alkane Molecules". J. Phys. Chem. 49 (11): 5116. doi:10.1063/1.1670007.
- Warshel A, Lifson S. (1970). "Consistent Force Field Calculations. II. Crystal Structure, Sublimation Energies, Molecular and Lattice Vibrations, Molecular Conformations and Enthalpies of Alkanes". J. Chem. Phys. 53 (2): 582. doi:10.1063/1.1674031.
- Warshel A, Levitt M (1976). "Theoretical Studies of Enzymatic Reactions: Dielectric Electrostatic and Steric Stabilization of the Carbonium Ion in the Reaction of Lysozyme". J. Mol. Biol. 103 (2): 227–249. doi:10.1016/0022-2836(76)90311-9. PMID 985660.
- Warshel A. (1976). "Bicycle-pedal Model for the First Step in the Vision Process". Nature 260 (5553): 679–683. doi:10.1038/260679a0. PMID 1264239.
- Warshel A. (2002). "Molecular Dynamics Simulations of Biological Reactions". Acc. Chem. Res. 35 (6): 385–395. doi:10.1021/ar010033z. PMID 12069623.
- Warshel A., Russel T. (1984). "Calculations of electrostatic interactions in biological systems and in solutions". Q.Rev.Biophys. 17: 283–421.
- Warshel A (1984). "Simulating the Energetics and Dynamics of Enzymatic Reactions". Pontificiae Academiae Scientiarum Scripta Varia 55: 60.
- Shneior Lifson
- Weizmann Institute of Science
- Harvard University
- MRC Laboratory for Molecular Biology
- Faculty profile, USC Dornsife
- Warshel research group at the University of Southern California
|Nobel Prize in Chemistry laureate
With: Martin Karplus